Names & Taxonomy
- Uniprot ID:
- Q92731
- Entry Name:
- ESR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
- Gene Names:
- ESR2 ESTRB NR3A2
- Gene Names Primary:
- ESR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 530
- Sequence:
- MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
- Cross Reference Drug Bank:
- DB00255 DB00783 DB01196 DB04573 DB04574 DB00481 DB00675 DB01108
- Gene Ontology Go:
- cilium
extracellular region
mitochondrion
neuron projection
nucleoplasm
nucleus
perikaryon
perinuclear region of cytoplasm
plasma membrane
protein-DNA complex
core promoter sequence-specific DNA binding
DNA binding
drug binding
enzyme binding
estradiol binding
estrogen receptor activity
estrogen response element binding
receptor antagonist activity
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid binding
steroid hormone binding
steroid hormone receptor activity
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
amygdala development
behavioral fear response
cell-cell signaling
cellular response to drug
cellular response to estradiol stimulus
cellular response to magnetism
cerebellum development
estrous cycle
extracellular negative regulation of signal transduction
gene expression
hypothalamus development
intracellular estrogen receptor signaling pathway
learning or memory
negative regulation of cell growth
negative regulation of epithelial cell proliferation
negative regulation of feeding behavior
negative regulation of neuron death
negative regulation of reactive oxygen species metabolic process
negative regulation of smooth muscle cell proliferation
negative regulation of transcription from RNA polymerase II promoter
ovarian follicle development
positive regulation of apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
prostate gland development
regulation of neuron apoptotic process
regulation of transcription, DNA-templated
response to activity
response to bisphenol A
response to dexamethasone
response to ethanol
response to genistein
response to human chorionic gonadotropin
response to insecticide
response to nutrient levels
response to salt
response to testosterone
response to water deprivation
Sertoli cell development
Sertoli cell proliferation
signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- amygdala development
behavioral fear response
cell-cell signaling
cellular response to drug
cellular response to estradiol stimulus
cellular response to magnetism
cerebellum development
estrous cycle
extracellular negative regulation of signal transduction
gene expression
hypothalamus development
intracellular estrogen receptor signaling pathway
learning or memory
negative regulation of cell growth
negative regulation of epithelial cell proliferation
negative regulation of feeding behavior
negative regulation of neuron death
negative regulation of reactive oxygen species metabolic process
negative regulation of smooth muscle cell proliferation
negative regulation of transcription from RNA polymerase II promoter
ovarian follicle development
positive regulation of apoptotic process
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of vasodilation
prostate gland development
regulation of neuron apoptotic process
regulation of transcription, DNA-templated
response to activity
response to bisphenol A
response to dexamethasone
response to ethanol
response to genistein
response to human chorionic gonadotropin
response to insecticide
response to nutrient levels
response to salt
response to testosterone
response to water deprivation
Sertoli cell development
Sertoli cell proliferation
signal transduction
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- core promoter sequence-specific DNA binding
DNA binding
drug binding
enzyme binding
estradiol binding
estrogen receptor activity
estrogen response element binding
receptor antagonist activity
RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
steroid binding
steroid hormone binding
steroid hormone receptor activity
transcription coactivator activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cilium
extracellular region
mitochondrion
neuron projection
nucleoplasm
nucleus
perikaryon
perinuclear region of cytoplasm
plasma membrane
protein-DNA complex - Keywords:
- 3D-structure
Activator
Alternative splicing
Complete proteome
DNA-binding
Lipid-binding
Metal-binding
Nucleus
Phosphoprotein
Receptor
Reference proteome
Steroid-binding
Transcription
Transcription regulation
Zinc
Zinc-finger - Interacts With:
- O15162; P53041; Q16881-4