Names & Taxonomy

Uniprot ID:
Q92696
Entry Name:
PGTA_HUMAN
Status:
reviewed
Protein Names:
Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)
Gene Names:
RABGGTA
Gene Names Primary:
RABGGTA
Organism:
Homo sapiens (Human)

Structure

Length:
567
Sequence:
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLGRLPEPNWTRELELCARFLEVDERNFHCWDYRRFVATQAAVPPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPEDVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRADPQDALRCLHVSRDEACLTVSFSRPLLVGSRMEILLLMVDDSPLIVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTAGDVQKECVLLKGRQEGWCRDSTTDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFQTLKAVDPMRATYLDDLRSKFLLENSVLKMEYAEVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRTLPPALAALRCLEVLQASDNAIESLDGVTNLPRLQELLLCNNRLQQPAVLQPLASCPRLVLLNLQGNPLCQAVGILEQLAELLPSVSSVLT
Proteomes:
UP000005640

Function

Function:
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Catalytic Activity:
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Enzyme Regulation:
ENZYME REGULATION: The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.
Gene Ontology Go:
Rab-protein geranylgeranyltransferase complex
Rab geranylgeranyltransferase activity
Rab GTPase binding
zinc ion binding
cellular protein modification process
protein geranylgeranylation
visual perception
Gene Ontology Biological Process:
cellular protein modification process
protein geranylgeranylation
visual perception
Gene Ontology Molecular Function:
Rab geranylgeranyltransferase activity
Rab GTPase binding
zinc ion binding
Gene Ontology Cellular Component:
Rab-protein geranylgeranyltransferase complex
Keywords:
Complete proteome
Leucine-rich repeat
Phosphoprotein
Polymorphism
Prenyltransferase
Reference proteome
Repeat
Transferase

Publication

PubMed ID:
8954794 9196026 14702039 15489334 7991565 18532927 21269460