Names & Taxonomy
- Uniprot ID:
- Q92581
- Entry Name:
- SL9A6_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6)
- Gene Names:
- SLC9A6 KIAA0267 NHE6
- Gene Names Primary:
- SLC9A6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 669
- Sequence:
- MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endosome membrane
Function
- Function:
- Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.
- Gene Ontology Go:
- axon terminus
axonal spine
cytoplasmic vesicle
dendrite
early endosome membrane
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
late endosome
plasma membrane
recycling endosome membrane
synapse
sodium:proton antiporter activity
axon extension
brain-derived neurotrophic factor receptor signaling pathway
dendrite extension
dendritic spine development
ion transport
neuron projection morphogenesis
regulation of neurotrophin TRK receptor signaling pathway
regulation of pH
sodium ion transmembrane transport
synapse organization
transmembrane transport
transport - Gene Ontology Biological Process:
- axon extension
brain-derived neurotrophic factor receptor signaling pathway
dendrite extension
dendritic spine development
ion transport
neuron projection morphogenesis
regulation of neurotrophin TRK receptor signaling pathway
regulation of pH
sodium ion transmembrane transport
synapse organization
transmembrane transport
transport - Gene Ontology Molecular Function:
- sodium:proton antiporter activity
- Gene Ontology Cellular Component:
- axonal spine
axon terminus
cytoplasmic vesicle
dendrite
early endosome membrane
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
late endosome
plasma membrane
recycling endosome membrane
synapse - Keywords:
- Alternative splicing
Antiport
Complete proteome
Endosome
Epilepsy
Glycoprotein
Ion transport
Isopeptide bond
Membrane
Mental retardation
Reference proteome
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport
Ubl conjugation