Names & Taxonomy
- Uniprot ID:
- Q92482
- Entry Name:
- AQP3_HUMAN
- Status:
- reviewed
- Protein Names:
- Aquaporin-3 (AQP-3) (Aquaglyceroporin-3)
- Gene Names:
- AQP3
- Gene Names Primary:
- AQP3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 292
- Sequence:
- MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane; Multi-pass membrane protein. Note=In collecting ducts of kidney.
Function
- Function:
- Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).
- Gene Ontology Go:
- basolateral plasma membrane
cell-cell junction
cytoplasm
integral component of membrane
nucleus
plasma membrane
glycerol channel activity
transporter activity
urea transmembrane transporter activity
water channel activity
excretion
ion transmembrane transport
odontogenesis
positive regulation of immune system process
regulation of keratinocyte differentiation
renal water absorption
renal water homeostasis
response to calcium ion
response to retinoic acid
response to vitamin D
transmembrane transport
transport
urea transmembrane transport
water transport - Gene Ontology Biological Process:
- excretion
ion transmembrane transport
odontogenesis
positive regulation of immune system process
regulation of keratinocyte differentiation
renal water absorption
renal water homeostasis
response to calcium ion
response to retinoic acid
response to vitamin D
transmembrane transport
transport
urea transmembrane transport
water transport - Gene Ontology Molecular Function:
- glycerol channel activity
transporter activity
urea transmembrane transporter activity
water channel activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
cell-cell junction
cytoplasm
integral component of membrane
nucleus
plasma membrane - Keywords:
- Alternative splicing
Blood group antigen
Cell membrane
Complete proteome
Glycoprotein
Membrane
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport