Names & Taxonomy

Uniprot ID:
Q8WWL2
Entry Name:
SPIR2_HUMAN
Status:
reviewed
Protein Names:
Protein spire homolog 2 (Spir-2)
Gene Names:
SPIRE2 KIAA1832 SPIR2
Gene Names Primary:
SPIRE2
Organism:
Homo sapiens (Human)

Structure

Length:
714
Sequence:
MARAGSCGGAAAGAGRPEPWELSLEEVLKAYEQPLNEEQAWAVCFQGCRGLRGSPGRRLRDTGDLLLRGDGSVGAREPEAAEPATMVVPLASSEAQTVQSLGFAIYRALDWGLDESEERELSPQLERLIDLMANNDSEDSGCGAADEGYGGPEEEEEAEGVPRSVRTFAQAMRLCAARLTDPRGAQAHYQAVCRALFVETLELRAFLARVREAKEMLQKLREDEPHLETPRAELDSLGHTDWARLWVQLMRELRRGVKLKKVQEQEFNPLPTEFQLTPFEMLMQDIRARNYKLRKVMVDGDIPPRVKKDAHELILDFIRSRPPLKQVSERRLRPLPPKQRSLHEKILEEIKQERRLRPVRGEGWAARGFGSLPCILNACSGDAKSTSCINLSVTDAGGSAQRPRPRVLLKAPTLAEMEEMNTSEEEESPCGEVTLKRDRSFSEHDLAQLRSEVASGLQSATHPPGGTEPPRPRAGSAHVWRPGSRDQGTCPASVSDPSHPLLSNRGSSGDRPEASMTPDAKHLWLEFSHPVESLALTVEEVMDVRRVLVKAEMEKFLQNKELFSSLKKGKICCCCRAKFPLFSWPPSCLFCKRAVCTSCSIKMKMPSKKFGHIPVYTLGFESPQRVSAAKTAPIQRRDIFQSLQGPQWQSVEEAFPHIYSHGCVLKDVCSECTSFVADVVRSSRKSVDVLNTTPRRSRQTQSLYIPNTRTLDFK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytoskeleton

Function

Function:
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.
Gene Ontology Go:
cell cortex
cleavage furrow
cytoplasmic vesicle membrane
cytoskeleton
cytosol
perinuclear region of cytoplasm
plasma membrane
actin cytoskeleton organization
actin nucleation
cleavage furrow formation
establishment of meiotic spindle localization
formin-nucleated actin cable assembly
intracellular transport
polar body extrusion after meiotic divisions
protein transport
vesicle-mediated transport
Gene Ontology Biological Process:
actin cytoskeleton organization
actin nucleation
cleavage furrow formation
establishment of meiotic spindle localization
formin-nucleated actin cable assembly
intracellular transport
polar body extrusion after meiotic divisions
protein transport
vesicle-mediated transport
Gene Ontology Cellular Component:
cell cortex
cleavage furrow
cytoplasmic vesicle membrane
cytoskeleton
cytosol
perinuclear region of cytoplasm
plasma membrane
Keywords:
Actin-binding
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Membrane
Phosphoprotein
Protein transport
Reference proteome
Repeat
Transport

Publication

PubMed ID:
11347906 15489334 17974005 18669648 21620703