Names & Taxonomy

Uniprot ID:
Q8WUD6
Entry Name:
CHPT1_HUMAN
Status:
reviewed
Protein Names:
Cholinephosphotransferase 1 (hCPT1) (EC 2.7.8.2) (AAPT1-like protein) (Diacylglycerol cholinephosphotransferase 1)
Gene Names:
CHPT1 CPT1 MSTP022
Gene Names Orf:
MSTP022
Gene Names Primary:
CHPT1
Organism:
Homo sapiens (Human)

Structure

Length:
406
Sequence:
MAAGAGAGSAPRWLRALSEPLSAAQLRRLEEHRYSAAGVSLLEPPLQLYWTWLLQWIPLWMAPNSITLLGLAVNVVTTLVLISYCPTATEEAPYWTYLLCALGLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAVGASIAARLGTYPDWFFFCSFIGMFVFYCAHWQTYVSGMLRFGKVDVTEIQIALVIVFVLSAFGGATMWDYTIPILEIKLKILPVLGFLGGVIFSCSNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLIIILAIMIYKKSATDVFEKHPCLYILMFGCVFAKVSQKLVVAHMTKSELYLQDTVFLGPGLLFLDQYFNNFIDEYVVLWMAMVISSFDMVIYFSALCLQISRHLHLNIFKTACHQAPEQVQVLSSKSHQNNMD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Golgi apparatus membrane

Function

Function:
Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
Pathway:
Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
Catalytic Activity:
CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Gene Ontology Go:
Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
diacylglycerol binding
diacylglycerol cholinephosphotransferase activity
metal ion binding
CDP-choline pathway
glycerophospholipid biosynthetic process
lipid metabolic process
phosphatidylcholine biosynthetic process
phospholipid metabolic process
platelet activating factor biosynthetic process
regulation of cell growth
small molecule metabolic process
Gene Ontology Biological Process:
CDP-choline pathway
glycerophospholipid biosynthetic process
lipid metabolic process
phosphatidylcholine biosynthetic process
phospholipid metabolic process
platelet activating factor biosynthetic process
regulation of cell growth
small molecule metabolic process
Gene Ontology Molecular Function:
diacylglycerol binding
diacylglycerol cholinephosphotransferase activity
metal ion binding
Gene Ontology Cellular Component:
Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
Keywords:
Acetylation
Alternative splicing
Complete proteome
Golgi apparatus
Lipid biosynthesis
Lipid metabolism
Magnesium
Manganese
Membrane
Metal-binding
Phospholipid biosynthesis
Phospholipid metabolism
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
10893425 16303743 15489334 16292752 12359261 12221122 22814378