Names & Taxonomy
- Uniprot ID:
- Q8WUD6
- Entry Name:
- CHPT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Cholinephosphotransferase 1 (hCPT1) (EC 2.7.8.2) (AAPT1-like protein) (Diacylglycerol cholinephosphotransferase 1)
- Gene Names:
- CHPT1 CPT1 MSTP022
- Gene Names Orf:
- MSTP022
- Gene Names Primary:
- CHPT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 406
- Sequence:
- MAAGAGAGSAPRWLRALSEPLSAAQLRRLEEHRYSAAGVSLLEPPLQLYWTWLLQWIPLWMAPNSITLLGLAVNVVTTLVLISYCPTATEEAPYWTYLLCALGLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAVGASIAARLGTYPDWFFFCSFIGMFVFYCAHWQTYVSGMLRFGKVDVTEIQIALVIVFVLSAFGGATMWDYTIPILEIKLKILPVLGFLGGVIFSCSNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLIIILAIMIYKKSATDVFEKHPCLYILMFGCVFAKVSQKLVVAHMTKSELYLQDTVFLGPGLLFLDQYFNNFIDEYVVLWMAMVISSFDMVIYFSALCLQISRHLHLNIFKTACHQAPEQVQVLSSKSHQNNMD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Golgi apparatus membrane
Function
- Function:
- Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
- Pathway:
- Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.
- Catalytic Activity:
- CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Gene Ontology Go:
- Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
diacylglycerol binding
diacylglycerol cholinephosphotransferase activity
metal ion binding
CDP-choline pathway
glycerophospholipid biosynthetic process
lipid metabolic process
phosphatidylcholine biosynthetic process
phospholipid metabolic process
platelet activating factor biosynthetic process
regulation of cell growth
small molecule metabolic process - Gene Ontology Biological Process:
- CDP-choline pathway
glycerophospholipid biosynthetic process
lipid metabolic process
phosphatidylcholine biosynthetic process
phospholipid metabolic process
platelet activating factor biosynthetic process
regulation of cell growth
small molecule metabolic process - Gene Ontology Molecular Function:
- diacylglycerol binding
diacylglycerol cholinephosphotransferase activity
metal ion binding - Gene Ontology Cellular Component:
- Golgi membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Golgi apparatus
Lipid biosynthesis
Lipid metabolism
Magnesium
Manganese
Membrane
Metal-binding
Phospholipid biosynthesis
Phospholipid metabolism
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix