Names & Taxonomy
- Uniprot ID:
- Q8WU17
- Entry Name:
- RN139_HUMAN
- Status:
- reviewed
- Protein Names:
- E3 ubiquitin-protein ligase RNF139 (EC 6.3.2.-) (RING finger protein 139) (Translocation in renal carcinoma on chromosome 8 protein)
- Gene Names:
- RNF139 TRC8
- Gene Names Primary:
- RNF139
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 664
- Sequence:
- MAAVGPPQQQVRMAHQQVWAALEVALRVPCLYIIDAIFNSYPDSSQSRFCIVLQIFLRLFGVFASSIVLILSQRSLFKFYTYSSAFLLAATSVLVNYYASLHIDFYGAYNTSAFGIELLPRKGPSLWMALIVLQLTFGIGYVTLLQIHSIYSQLIILDLLVPVIGLITELPLHIRETLLFTSSLILTLNTVFVLAVKLKWFYYSTRYVYLLVRHMYRIYGLQLLMEDTWKRIRFPDILRVFWLTRVTAQATVLMYILRMANETDSFFISWDDFWDLICNLIISGCDSTLTVLGMSAVISSVAHYLGLGILAFIGSTEEDDRRLGFVAPVLFFILALQTGLSGLRPEERLIRLSRNMCLLLTAVLHFIHGMTDPVLMSLSASHVSSFRRHFPVLFVSACLFILPVLLSYVLWHHYALNTWLFAVTAFCVELCLKVIVSLTVYTLFMIDGYYNVLWEKLDDYVYYVRSTGSIIEFIFGVVMFGNGAYTMMFESGSKIRAFMMCLHAYFNIYLQAKNGWKTFMNRRTAVKKINSLPEIKGSRLQEINDVCAICYHEFTTSARITPCNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAAAESDRELNEDDSTDCDDDVQRERNGVIQHTGAAAEEFNDDTD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor.
- Pathway:
- Protein modification; protein ubiquitination.
- Gene Ontology Go:
- Derlin-1 retrotranslocation complex
endoplasmic reticulum
integral component of membrane
ligase activity
protease binding
receptor activity
ubiquitin protein ligase activity
ubiquitin-like protein transferase activity
ubiquitin-protein transferase activity
zinc ion binding
ERAD pathway
negative regulation of cell proliferation
negative regulation of translation
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein destabilization
protein polyubiquitination
protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of ER to Golgi vesicle-mediated transport
regulation of protein processing
regulation of protein ubiquitination - Gene Ontology Biological Process:
- ERAD pathway
negative regulation of cell proliferation
negative regulation of translation
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
protein destabilization
protein polyubiquitination
protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of ER to Golgi vesicle-mediated transport
regulation of protein processing
regulation of protein ubiquitination - Gene Ontology Molecular Function:
- ligase activity
protease binding
receptor activity
ubiquitin-like protein transferase activity
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
zinc ion binding - Gene Ontology Cellular Component:
- Derlin-1 retrotranslocation complex
endoplasmic reticulum
integral component of membrane - Keywords:
- Acetylation
Chromosomal rearrangement
Complete proteome
Endoplasmic reticulum
Ligase
Membrane
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Transmembrane
Transmembrane helix
Ubl conjugation
Ubl conjugation pathway
Zinc
Zinc-finger - Interacts With:
- Q8TCT9; P40337