Names & Taxonomy
- Uniprot ID:
- Q8WU03
- Entry Name:
- GLYL2_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycine N-acyltransferase-like protein 2 (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase-like protein 2)
- Gene Names:
- GLYATL2
- Gene Names Primary:
- GLYATL2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 294
- Sequence:
- MLVLHNSQKLQILYKSLEKSIPESIKVYGAIFNIKDKNPFNMEVLVDAWPDYQIVITRPQKQEMKDDQDHYTNTYHIFTKAPDKLEEVLSYSNVISWEQTLQIQGCQEGLDEAIRKVATSKSVQVDYMKTILFIPELPKKHKTSSNDKMELFEVDDDNKEGNFSNMFLDASHAGLVNEHWAFGKNERSLKYIERCLQDFLGFGVLGPEGQLVSWIVMEQSCELRMGYTVPKYRHQGNMLQIGYHLEKYLSQKEIPFYFHVADNNEKSLQALNNLGFKICPCGWHQWKCTPKKYC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum
Function
- Function:
- Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.
- Catalytic Activity:
- Acyl-CoA + glycine = CoA + N-acylglycine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=4.4 uM for oleoyl-CoA
- Cross Reference Drug Bank:
- DB00145
- Gene Ontology Go:
- endoplasmic reticulum
mitochondrion
glycine N-acyltransferase activity - Gene Ontology Molecular Function:
- glycine N-acyltransferase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum
mitochondrion - Keywords:
- Acetylation
Acyltransferase
Complete proteome
Endoplasmic reticulum
Polymorphism
Reference proteome
Transferase