Names & Taxonomy
- Uniprot ID:
- Q8WTV0
- Entry Name:
- SCRB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36)
- Gene Names:
- SCARB1 CD36L1 CLA1
- Gene Names Primary:
- SCARB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 552
- Sequence:
- MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein. Note=Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Function
- Function:
- Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity).
- Cross Reference Drug Bank:
- DB00144
- Gene Ontology Go:
- caveola
cell surface
endocytic vesicle membrane
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
lysosomal membrane
microvillus membrane
plasma membrane
1-phosphatidylinositol binding
apolipoprotein A-I binding
apolipoprotein binding
high-density lipoprotein particle binding
high-density lipoprotein particle receptor activity
lipopolysaccharide binding
lipopolysaccharide receptor activity
low-density lipoprotein particle binding
phosphatidylserine binding
transporter activity
virus receptor activity
adhesion of symbiont to host
androgen biosynthetic process
blood vessel endothelial cell migration
cholesterol catabolic process
cholesterol efflux
cholesterol homeostasis
cholesterol import
detection of lipopolysaccharide
endothelial cell proliferation
high-density lipoprotein particle clearance
high-density lipoprotein particle remodeling
intestinal absorption
lipopolysaccharide transport
lipopolysaccharide-mediated signaling pathway
lipoprotein metabolic process
low-density lipoprotein particle clearance
phospholipid transport
positive regulation of cholesterol storage
positive regulation of endothelial cell migration
positive regulation of nitric-oxide synthase activity
positive regulation of triglyceride biosynthetic process
receptor-mediated endocytosis
recognition of apoptotic cell
regulation of phagocytosis
regulation of phosphatidylcholine catabolic process
reverse cholesterol transport
small molecule metabolic process
triglyceride homeostasis
vitamin transmembrane transport
wound healing - Gene Ontology Biological Process:
- adhesion of symbiont to host
androgen biosynthetic process
blood vessel endothelial cell migration
cholesterol catabolic process
cholesterol efflux
cholesterol homeostasis
cholesterol import
detection of lipopolysaccharide
endothelial cell proliferation
high-density lipoprotein particle clearance
high-density lipoprotein particle remodeling
intestinal absorption
lipopolysaccharide-mediated signaling pathway
lipopolysaccharide transport
lipoprotein metabolic process
low-density lipoprotein particle clearance
phospholipid transport
positive regulation of cholesterol storage
positive regulation of endothelial cell migration
positive regulation of nitric-oxide synthase activity
positive regulation of triglyceride biosynthetic process
receptor-mediated endocytosis
recognition of apoptotic cell
regulation of phagocytosis
regulation of phosphatidylcholine catabolic process
reverse cholesterol transport
small molecule metabolic process
triglyceride homeostasis
vitamin transmembrane transport
wound healing - Gene Ontology Molecular Function:
- 1-phosphatidylinositol binding
apolipoprotein A-I binding
apolipoprotein binding
high-density lipoprotein particle binding
high-density lipoprotein particle receptor activity
lipopolysaccharide binding
lipopolysaccharide receptor activity
low-density lipoprotein particle binding
phosphatidylserine binding
transporter activity
virus receptor activity - Gene Ontology Cellular Component:
- caveola
cell surface
endocytic vesicle membrane
extracellular exosome
integral component of plasma membrane
intracellular membrane-bounded organelle
lysosomal membrane
microvillus membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transmembrane
Transmembrane helix - Interacts With:
- P27958; P60411; P26371