Names & Taxonomy
- Uniprot ID:
- Q8WTS6
- Entry Name:
- SETD7_HUMAN
- Status:
- reviewed
- Protein Names:
- Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9)
- Gene Names:
- SETD7 KIAA1717 KMT7 SET7 SET9
- Gene Names Primary:
- SETD7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 366
- Sequence:
- MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDGRLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Chromosome
Function
- Function:
- Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the --K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
- Catalytic Activity:
- S-adenosyl-L-methionine + L-lysine- = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=29 uM for histone H3
- Gene Ontology Go:
- chromosome
nucleolus
nucleoplasm
chromatin binding
histone-lysine N-methyltransferase activity
p53 binding
protein-lysine N-methyltransferase activity
cellular response to DNA damage stimulus
chromatin modification
chromatin organization
heterochromatin organization
peptidyl-lysine dimethylation
peptidyl-lysine monomethylation
positive regulation of transcription, DNA-templated
regulation of histone H3-K9 methylation
response to ethanol
transcription, DNA-templated - Gene Ontology Biological Process:
- cellular response to DNA damage stimulus
chromatin modification
chromatin organization
heterochromatin organization
peptidyl-lysine dimethylation
peptidyl-lysine monomethylation
positive regulation of transcription, DNA-templated
regulation of histone H3-K9 methylation
response to ethanol
transcription, DNA-templated - Gene Ontology Molecular Function:
- chromatin binding
histone-lysine N-methyltransferase activity
p53 binding
protein-lysine N-methyltransferase activity - Gene Ontology Cellular Component:
- chromosome
nucleolus
nucleoplasm - Keywords:
- 3D-structure
Activator
Chromatin regulator
Chromosome
Complete proteome
Direct protein sequencing
Methyltransferase
Nucleus
Reference proteome
Repeat
S-adenosyl-L-methionine
Transcription
Transcription regulation
Transferase - Interacts With:
- Q9WVH4; P68431; P68433; Q96RI1; P06400; Q04206; Q04207; Q9UHV2; Q12962; P04637