Names & Taxonomy
- Uniprot ID:
- Q8TF76
- Entry Name:
- HASP_HUMAN
- Status:
- reviewed
- Protein Names:
- Serine/threonine-protein kinase haspin (EC 2.7.11.1) (Germ cell-specific gene 2 protein) (H-haspin) (Haploid germ cell-specific nuclear protein kinase)
- Gene Names:
- GSG2
- Gene Names Primary:
- GSG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 798
- Sequence:
- MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQSDDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRARPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSPTPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRASLRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSCQERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQKLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSECSNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.
Function
- Function:
- Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Constitutive activity that does not require phosphorylation. Specifically inhibited by 3-(1H-indazol-5-yl)-N-propylimidazopyridazin-6-amine (CHR-6494).
- Active Site:
- ACT_SITE 649 649 Proton acceptor.
- Gene Ontology Go:
- centrosome
chromosome
cytoplasm
nucleus
spindle
ATP binding
histone kinase activity (H3-T3 specific)
protein kinase activity
histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore
intracellular signal transduction
mitotic sister chromatid cohesion
protein localization to chromosome, centromeric region
protein phosphorylation
regulation of spindle checkpoint - Gene Ontology Biological Process:
- histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore
intracellular signal transduction
mitotic sister chromatid cohesion
protein localization to chromosome, centromeric region
protein phosphorylation
regulation of spindle checkpoint - Gene Ontology Molecular Function:
- ATP binding
histone kinase activity (H3-T3 specific)
protein kinase activity - Gene Ontology Cellular Component:
- centrosome
chromosome
cytoplasm
nucleus
spindle - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell cycle
Chromatin regulator
Chromosome
Complete proteome
Cytoplasm
Cytoskeleton
Kinase
Magnesium
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase - Interacts With:
- P08238