Names & Taxonomy
- Uniprot ID:
- Q8TED1
- Entry Name:
- GPX8_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable glutathione peroxidase 8 (GPx-8) (GSHPx-8) (EC 1.11.1.9)
- Gene Names:
- GPX8 UNQ847/PRO1785
- Gene Names Orf:
- UNQ847/PRO1785
- Gene Names Primary:
- GPX8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 209
- Sequence:
- MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTVSLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSKEVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKFWKPEEPIEVIRPDIAALVRQVIIKKKEDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Catalytic Activity:
- 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
- Active Site:
- ACT_SITE 79 79
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- endoplasmic reticulum lumen
integral component of membrane
glutathione peroxidase activity
peroxidase activity
cellular oxidant detoxification
response to reactive oxygen species - Gene Ontology Biological Process:
- cellular oxidant detoxification
response to reactive oxygen species - Gene Ontology Molecular Function:
- glutathione peroxidase activity
peroxidase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum lumen
integral component of membrane - Keywords:
- 3D-structure
Acetylation
Complete proteome
Membrane
Oxidoreductase
Peroxidase
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix