Names & Taxonomy
- Uniprot ID:
- Q8TDI8
- Entry Name:
- TMC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Transmembrane channel-like protein 1 (Transmembrane cochlear-expressed protein 1)
- Gene Names:
- TMC1
- Gene Names Primary:
- TMC1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 760
- Sequence:
- MSPKKVQIKVEEKEDETEESSSEEEEEVEDKLPRRESLRPKRKRTRDVINEDDPEPEPEDEETRKAREKERRRRLKRGAEEEEIDEEELERLKAELDEKRQIIATVKCKPWKMEKKIEVLKEAKKFVSENEGALGKGKGKRWFAFKMMMAKKWAKFLRDFENFKAACVPWENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTVPRAEEASAANFGVLYDFNGLAQYSVLFYGYYDNKRTIGWMNFRLPLSYFLVGIMCIGYSFLVVLKAMTKNIGDDGGGDDNTFNFSWKVFTSWDYLIGNPETADNKFNSITMNFKEAITEEKAAQVEENVHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQEFAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLGNLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPADVPRGPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFVRFCNYCWCWDLEYGYPSYTEFDISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASRSNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAKILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALENKMRNKKMAAARAAAAAGRQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Probable ion channel required for the normal function of cochlear hair cells.
- Gene Ontology Go:
- external side of plasma membrane
integral component of membrane
stereocilium tip
voltage-gated calcium channel activity
auditory receptor cell development
detection of mechanical stimulus involved in sensory perception of sound
vestibular reflex - Gene Ontology Biological Process:
- auditory receptor cell development
detection of mechanical stimulus involved in sensory perception of sound
vestibular reflex - Gene Ontology Molecular Function:
- voltage-gated calcium channel activity
- Gene Ontology Cellular Component:
- external side of plasma membrane
integral component of membrane
stereocilium tip - Keywords:
- Complete proteome
Deafness
Disease mutation
Hearing
Ion channel
Ion transport
Membrane
Non-syndromic deafness
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport