Names & Taxonomy
- Uniprot ID:
- Q8TD30
- Entry Name:
- ALAT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2)
- Gene Names:
- GPT2 AAT2 ALT2
- Gene Names Primary:
- GPT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 523
- Sequence:
- MQRAAALVRRGCGPRTPSSWGRSQSSAAAEASAVLKVRPERSRRERILTLESMNPQVKAVEYAVRGPIVLKAGEIELELQRGIKKPFTEVIRANIGDAQAMGQQPITFLRQVMALCTYPNLLDSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIREDVAAYITRRDGGVPADPDNIYLTTGASDGISTILKILVSGGGKSRTGVMIPIPQYPLYSAVISELDAIQVNYYLDEENCWALNVNELRRAVQEAKDHCDPKVLCIINPGNPTGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYEMGPEYSSNVELASFHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPVAGEESFEQFSREKESVLGNLAKKAKLTEDLFNQVPGIHCNPLQGAMYAFPRIFIPAKAVEAAQAHQMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLQKVKDFHINFLEKYA
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
- Pathway:
- Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.
- Catalytic Activity:
- L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00160 DB00780
- Gene Ontology Go:
- mitochondrial matrix
L-alanine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding
2-oxoglutarate metabolic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-alanine catabolic process
L-alanine metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- 2-oxoglutarate metabolic process
cellular amino acid biosynthetic process
cellular nitrogen compound metabolic process
L-alanine catabolic process
L-alanine metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- L-alanine:2-oxoglutarate aminotransferase activity
pyridoxal phosphate binding - Gene Ontology Cellular Component:
- mitochondrial matrix
- Keywords:
- 3D-structure
Acetylation
Alternative splicing
Aminotransferase
Complete proteome
Disease mutation
Mental retardation
Pyridoxal phosphate
Reference proteome
Transferase