Names & Taxonomy

Uniprot ID:
Q8TCW9
Entry Name:
PKR1_HUMAN
Status:
reviewed
Protein Names:
Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a)
Gene Names:
PROKR1 GPR73 PKR1
Gene Names Primary:
PROKR1
Organism:
Homo sapiens (Human)

Structure

Length:
393
Sequence:
METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
neuropeptide Y receptor activity
cell surface receptor signaling pathway
circadian rhythm
G-protein coupled receptor signaling pathway
negative regulation of apoptotic process
Gene Ontology Biological Process:
cell surface receptor signaling pathway
circadian rhythm
G-protein coupled receptor signaling pathway
negative regulation of apoptotic process
Gene Ontology Molecular Function:
G-protein coupled receptor activity
neuropeptide Y receptor activity
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix

Publication

PubMed ID:
12054613 12427552 11886876 15815621 15489334 18339712