Names & Taxonomy
- Uniprot ID:
- Q8TCW9
- Entry Name:
- PKR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Prokineticin receptor 1 (PK-R1) (G-protein coupled receptor 73) (G-protein coupled receptor ZAQ) (GPR73a)
- Gene Names:
- PROKR1 GPR73 PKR1
- Gene Names Primary:
- PROKR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 393
- Sequence:
- METTMGFMDDNATNTSTSFLSVLNPHGAHATSFPFNFSYSDYDMPLDEDEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFIAALVRYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCTSVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTATGLIALVWTVSILIAIPSAYFTTETVLVIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGIEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYIVECIAMSNSMINTLCFVTVKNDTVKYFKKIMLLHWKASYNGGKSSADLDLKTIGMPATEEVDCIRLK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
neuropeptide Y receptor activity
cell surface receptor signaling pathway
circadian rhythm
G-protein coupled receptor signaling pathway
negative regulation of apoptotic process - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
circadian rhythm
G-protein coupled receptor signaling pathway
negative regulation of apoptotic process - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
neuropeptide Y receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix