Names & Taxonomy

Uniprot ID:
Q8TAE7
Entry Name:
KCNG3_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv10.1) (Voltage-gated potassium channel subunit Kv6.3)
Gene Names:
KCNG3
Gene Names Primary:
KCNG3
Organism:
Homo sapiens (Human)

Structure

Length:
436
Sequence:
MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSTEFLN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane
Intramembrane:
INTRAMEM 361 372 Helical; Name=Pore helix.

Function

Function:
Potassium channel subunit that does not form functional channels by itself (PubMed:11852086). Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1 (PubMed:11852086, PubMed:19074135).
Gene Ontology Go:
endoplasmic reticulum
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
potassium ion transmembrane transport
protein homooligomerization
synaptic transmission
Gene Ontology Biological Process:
potassium ion transmembrane transport
protein homooligomerization
synaptic transmission
Gene Ontology Molecular Function:
delayed rectifier potassium channel activity
Gene Ontology Cellular Component:
endoplasmic reticulum
plasma membrane
voltage-gated potassium channel complex
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Ion channel
Ion transport
Membrane
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
11852086 12060745 15815621 15489334 19074135