Names & Taxonomy

Uniprot ID:
Q8NI22
Entry Name:
MCFD2_HUMAN
Status:
reviewed
Protein Names:
Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein)
Gene Names:
MCFD2 SDNSF
Gene Names Primary:
MCFD2
Organism:
Homo sapiens (Human)

Structure

Length:
146
Sequence:
MTMRSLLRTPFLCGLLWAFCAPGARAEEPAASFSQPGSMGLDKNTVHDQEHIMEHLEGVINKPEAEMSPQELQLHYFKMHDYDGNNLLDGLELSTAITHVHKEEGSEQAPLMSEDELINIIDGVLRDDDKNNDGYIDYAEFAKSLQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum-Golgi intermediate compartment

Function

Function:
The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors.
Cross Reference Drug Bank:
DB00025
Gene Ontology Go:
endoplasmic reticulum membrane
endoplasmic reticulum-Golgi intermediate compartment membrane
ER to Golgi transport vesicle membrane
Golgi membrane
calcium ion binding
cellular protein metabolic process
COPII vesicle coating
ER to Golgi vesicle-mediated transport
membrane organization
post-translational protein modification
protein N-linked glycosylation via asparagine
protein transport
Gene Ontology Biological Process:
cellular protein metabolic process
COPII vesicle coating
ER to Golgi vesicle-mediated transport
membrane organization
post-translational protein modification
protein N-linked glycosylation via asparagine
protein transport
Gene Ontology Molecular Function:
calcium ion binding
Gene Ontology Cellular Component:
endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum membrane
ER to Golgi transport vesicle membrane
Golgi membrane
Keywords:
3D-structure
Alternative splicing
Calcium
Complete proteome
Disease mutation
ER-Golgi transport
Endoplasmic reticulum
Golgi apparatus
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Repeat
Signal
Transport

Publication

PubMed ID:
12717434 14702039 17974005 15815621 15489334 21269460 24275569 25944712 18590741 20138881 20142513 18685427 20491958