Names & Taxonomy
- Uniprot ID:
- Q8NHX9
- Entry Name:
- TPC2_HUMAN
- Status:
- reviewed
- Protein Names:
- Two pore calcium channel protein 2 (Voltage-dependent calcium channel protein TPC2)
- Gene Names:
- TPCN2 TPC2
- Gene Names Primary:
- TPCN2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 752
- Sequence:
- MAEPQAESEPLLGGARGGGGDWPAGLTTYRSIQVGPGAAARWDLCIDQAVVFIEDAIQYRSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLAFIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLWLLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLLQNSSMMKKTLKCIRWSLPEMASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNPDVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTRAAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEEFQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVLDADVLPAERDDFILGILNCVFIVYYLLEMLLKVFALGLRGYLSYPSNVFDGLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKLMAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSLAPANGSAPCGSFEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVLWWLVSSVIWVNLFLALILENFLHKWDPRSHLQPLAGTPEATYQMTVELLFRDILEEPGEDELTERLSQHPHLWLCR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome membrane
- Intramembrane:
- INTRAMEM 255 279 Helical; Pore-forming.
Function
- Function:
- Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.
- Gene Ontology Go:
- endosome membrane
integral component of membrane
lysosomal membrane
lysosome
plasma membrane
identical protein binding
NAADP-sensitive calcium-release channel activity
protein kinase binding
voltage-gated calcium channel activity
calcium-mediated signaling
cellular calcium ion homeostasis
ion transmembrane transport
lysosome organization
membrane depolarization during action potential
regulation of autophagy
response to vitamin D
smooth muscle contraction
transmembrane transport - Gene Ontology Biological Process:
- calcium-mediated signaling
cellular calcium ion homeostasis
ion transmembrane transport
lysosome organization
membrane depolarization during action potential
regulation of autophagy
response to vitamin D
smooth muscle contraction
transmembrane transport - Gene Ontology Molecular Function:
- identical protein binding
NAADP-sensitive calcium-release channel activity
protein kinase binding
voltage-gated calcium channel activity - Gene Ontology Cellular Component:
- endosome membrane
integral component of membrane
lysosomal membrane
lysosome
plasma membrane - Keywords:
- Calcium
Calcium channel
Calcium transport
Complete proteome
Glycoprotein
Ion channel
Ion transport
Lysosome
Membrane
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel - Interacts With:
- Itself; O00165; P42345; Q9ULQ1