Names & Taxonomy

Uniprot ID:
Q8NFY4
Entry Name:
SEM6D_HUMAN
Status:
reviewed
Protein Names:
Semaphorin-6D
Gene Names:
SEMA6D KIAA1479
Gene Names Primary:
SEMA6D
Organism:
Homo sapiens (Human)

Structure

Length:
1073
Sequence:
MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cell membrane; Single-pass type I membrane protein.; Isoform 3: Cell membrane; Single-pass type I membrane protein.; Isoform 4: Cell membrane; Single-pass type I membrane protein.; Isoform 5: Cell membrane; Single-pass type I membrane protein.; Isoform 7: Cytoplasm.

Function

Function:
Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.
Gene Ontology Go:
cytoplasm
integral component of plasma membrane
plasma membrane
chemorepellent activity
semaphorin receptor binding
axon guidance
negative chemotaxis
negative regulation of axon extension involved in axon guidance
negative regulation of smooth muscle cell migration
neural crest cell migration
positive regulation of cell migration
positive regulation of smooth muscle cell migration
semaphorin-plexin signaling pathway
ventricular system development
Gene Ontology Biological Process:
axon guidance
negative chemotaxis
negative regulation of axon extension involved in axon guidance
negative regulation of smooth muscle cell migration
neural crest cell migration
positive regulation of cell migration
positive regulation of smooth muscle cell migration
semaphorin-plexin signaling pathway
ventricular system development
Gene Ontology Molecular Function:
chemorepellent activity
semaphorin receptor binding
Gene Ontology Cellular Component:
cytoplasm
integral component of plasma membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Membrane
Neurogenesis
Phosphoprotein
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
12110693 10819331 12168954 16572171 15489334