Names & Taxonomy

Uniprot ID:
Q8NFT2
Entry Name:
STEA2_HUMAN
Status:
reviewed
Protein Names:
Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1)
Gene Names:
STEAP2 PCANAP1 STAMP1 UNQ6507/PRO23203
Gene Names Orf:
UNQ6507/PRO23203
Gene Names Primary:
STEAP2
Organism:
Homo sapiens (Human)

Structure

Length:
490
Sequence:
MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endosome membrane

Function

Function:
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).
Cofactor:
COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
Gene Ontology Go:
cytosol
early endosome
endosome membrane
integral component of Golgi membrane
intracellular membrane-bounded organelle
plasma membrane
trans-Golgi network transport vesicle
cupric reductase activity
ferric-chelate reductase (NADPH) activity
metal ion binding
transporter activity
copper ion import
endocytosis
ferric iron import into cell
Golgi to plasma membrane transport
iron ion homeostasis
regulated exocytosis
response to hormone
Gene Ontology Biological Process:
copper ion import
endocytosis
ferric iron import into cell
Golgi to plasma membrane transport
iron ion homeostasis
regulated exocytosis
response to hormone
Gene Ontology Molecular Function:
cupric reductase activity
ferric-chelate reductase (NADPH) activity
metal ion binding
transporter activity
Gene Ontology Cellular Component:
cytosol
early endosome
endosome membrane
integral component of Golgi membrane
intracellular membrane-bounded organelle
plasma membrane
trans-Golgi network transport vesicle
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Copper
Electron transport
Endosome
FAD
Flavoprotein
Heme
Ion transport
Iron
Iron transport
Membrane
Metal-binding
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
12095985 12429817 12975309 12853948 12690205 16609065 18669648