Names & Taxonomy
- Uniprot ID:
- Q8NFT2
- Entry Name:
- STEA2_HUMAN
- Status:
- reviewed
- Protein Names:
- Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1)
- Gene Names:
- STEAP2 PCANAP1 STAMP1 UNQ6507/PRO23203
- Gene Names Orf:
- UNQ6507/PRO23203
- Gene Names Primary:
- STEAP2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 490
- Sequence:
- MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endosome membrane
Function
- Function:
- Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Gene Ontology Go:
- cytosol
early endosome
endosome membrane
integral component of Golgi membrane
intracellular membrane-bounded organelle
plasma membrane
trans-Golgi network transport vesicle
cupric reductase activity
ferric-chelate reductase (NADPH) activity
metal ion binding
transporter activity
copper ion import
endocytosis
ferric iron import into cell
Golgi to plasma membrane transport
iron ion homeostasis
regulated exocytosis
response to hormone - Gene Ontology Biological Process:
- copper ion import
endocytosis
ferric iron import into cell
Golgi to plasma membrane transport
iron ion homeostasis
regulated exocytosis
response to hormone - Gene Ontology Molecular Function:
- cupric reductase activity
ferric-chelate reductase (NADPH) activity
metal ion binding
transporter activity - Gene Ontology Cellular Component:
- cytosol
early endosome
endosome membrane
integral component of Golgi membrane
intracellular membrane-bounded organelle
plasma membrane
trans-Golgi network transport vesicle - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Copper
Electron transport
Endosome
FAD
Flavoprotein
Heme
Ion transport
Iron
Iron transport
Membrane
Metal-binding
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport