Names & Taxonomy

Uniprot ID:
Q8NET8
Entry Name:
TRPV3_HUMAN
Status:
reviewed
Protein Names:
Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3)
Gene Names:
TRPV3
Gene Names Primary:
TRPV3
Organism:
Homo sapiens (Human)

Structure

Length:
790
Sequence:
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.
Intramembrane:
INTRAMEM 621 637 Pore-forming.

Function

Function:
Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).
Cross Reference Drug Bank:
DB00825
Gene Ontology Go:
integral component of membrane
plasma membrane
receptor complex
calcium channel activity
calcium ion transmembrane transport
ion transmembrane transport
negative regulation of hair cycle
positive regulation of calcium ion import
response to heat
transmembrane transport
Gene Ontology Biological Process:
calcium ion transmembrane transport
ion transmembrane transport
negative regulation of hair cycle
positive regulation of calcium ion import
response to heat
transmembrane transport
Gene Ontology Molecular Function:
calcium channel activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
receptor complex
Keywords:
ANK repeat
Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Ion channel
Ion transport
Membrane
Palmoplantar keratoderma
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
12077606 12077604 21593771 25285920 22405088 22835024