Names & Taxonomy
- Uniprot ID:
- Q8NER5
- Entry Name:
- ACV1C_HUMAN
- Status:
- reviewed
- Protein Names:
- Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7)
- Gene Names:
- ACVR1C ALK7
- Gene Names Primary:
- ACVR1C
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 493
- Sequence:
- MTRALCSALRQALLLLAAAAELSPGLKCVCLLCDSSNFTCQTEGACWASVMLTNGKEQVIKSCVSLPELNAQVFCHSSNNVTKTECCFTDFCNNITLHLPTASPNAPKLGPMELAIIITVPVCLLSIAAMLTVWACQGRQCSYRKKKRPNVEEPLSECNLVNAGKTLKDLIYDVTASGSGSGLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQGKPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPEMLDDTMNVNIFESFKRADIYSVGLVYWEIARRCSVGGIVEEYQLPYYDMVPSDPSIEEMRKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTISQLCVKEDCKA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
- Catalytic Activity:
- ATP + = ADP + phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 323 323 Proton acceptor.
- Gene Ontology Go:
- activin receptor complex
plasma membrane
activin receptor activity, type I
ATP binding
growth factor binding
metal ion binding
nodal binding
receptor signaling protein serine/threonine kinase activity
apoptotic nuclear changes
cell differentiation
lipid storage
negative regulation of chorionic trophoblast cell proliferation
negative regulation of insulin secretion
negative regulation of trophoblast cell migration
nodal signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein phosphorylation
response to dietary excess
response to glucose
response to insulin - Gene Ontology Biological Process:
- apoptotic nuclear changes
cell differentiation
lipid storage
negative regulation of chorionic trophoblast cell proliferation
negative regulation of insulin secretion
negative regulation of trophoblast cell migration
nodal signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein phosphorylation
response to dietary excess
response to glucose
response to insulin - Gene Ontology Molecular Function:
- activin receptor activity, type I
ATP binding
growth factor binding
metal ion binding
nodal binding
receptor signaling protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- activin receptor complex
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Apoptosis
Complete proteome
Kinase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Polymorphism
Receptor
Reference proteome
Serine/threonine-protein kinase
Signal
Transferase
Transmembrane
Transmembrane helix