Names & Taxonomy
- Uniprot ID:
- Q8NDX2
- Entry Name:
- VGLU3_HUMAN
- Status:
- reviewed
- Protein Names:
- Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8)
- Gene Names:
- SLC17A8 VGLUT3
- Gene Names Primary:
- SLC17A8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 589
- Sequence:
- MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRQILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPENLSEEKCGIIDQDELAEEIELNHESFASPKKKMSYGATSQNCEVQKKEWKGQRGATLDEEELTSYQNEERNFSTIS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Function
- Function:
- Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
- Gene Ontology Go:
- apical dendrite
axon terminus
basilar dendrite
cell junction
excitatory synapse
glial limiting end-foot
integral component of membrane
multivesicular body
pericellular basket
perikaryon
synaptic vesicle membrane
L-glutamate transmembrane transporter activity
symporter activity
brain development
cochlea development
ion transport
neural retina development
neurotransmitter transport
sensory perception of sound
sodium ion transport
transmembrane transport - Gene Ontology Biological Process:
- brain development
cochlea development
ion transport
neural retina development
neurotransmitter transport
sensory perception of sound
sodium ion transport
transmembrane transport - Gene Ontology Molecular Function:
- L-glutamate transmembrane transporter activity
symporter activity - Gene Ontology Cellular Component:
- apical dendrite
axon terminus
basilar dendrite
cell junction
excitatory synapse
glial limiting end-foot
integral component of membrane
multivesicular body
pericellular basket
perikaryon
synaptic vesicle membrane - Keywords:
- Alternative splicing
Cell junction
Complete proteome
Cytoplasmic vesicle
Deafness
Disease mutation
Glycoprotein
Hearing
Ion transport
Membrane
Neurotransmitter transport
Non-syndromic deafness
Polymorphism
Reference proteome
Sodium
Sodium transport
Symport
Synapse
Synaptosome
Transmembrane
Transmembrane helix
Transport