Names & Taxonomy

Uniprot ID:
Q8NBQ5
Entry Name:
DHB11_HUMAN
Status:
reviewed
Protein Names:
Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2)
Gene Names:
HSD17B11 DHRS8 PAN1B SDR16C2 PSEC0029 UNQ207/PRO233
Gene Names Orf:
PSEC0029 UNQ207/PRO233
Gene Names Primary:
HSD17B11
Organism:
Homo sapiens (Human)

Structure

Length:
300
Sequence:
MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMKAQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
Catalytic Activity:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Active Site:
ACT_SITE 185 185 Proton acceptor.
Gene Ontology Go:
cytoplasm
cytosol
extracellular region
intracellular membrane-bounded organelle
lipid particle
estradiol 17-beta-dehydrogenase activity
steroid dehydrogenase activity
androgen catabolic process
estrogen biosynthetic process
small molecule metabolic process
steroid metabolic process
Gene Ontology Biological Process:
androgen catabolic process
estrogen biosynthetic process
small molecule metabolic process
steroid metabolic process
Gene Ontology Molecular Function:
estradiol 17-beta-dehydrogenase activity
steroid dehydrogenase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular region
intracellular membrane-bounded organelle
lipid particle
Keywords:
3D-structure
Complete proteome
Lipid biosynthesis
Lipid metabolism
NADP
Oxidoreductase
Reference proteome
Secreted
Signal
Steroid biosynthesis

Publication

PubMed ID:
10800688 14996095 12975309 16303743 15815621 15489334 9888557 11165019 12697717 21269460 24275569