Names & Taxonomy
- Uniprot ID:
- Q8NBQ5
- Entry Name:
- DHB11_HUMAN
- Status:
- reviewed
- Protein Names:
- Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2)
- Gene Names:
- HSD17B11 DHRS8 PAN1B SDR16C2 PSEC0029 UNQ207/PRO233
- Gene Names Orf:
- PSEC0029 UNQ207/PRO233
- Gene Names Primary:
- HSD17B11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 300
- Sequence:
- MKFLLDILLLLPLLIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPSTSLGPTLEPEEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFLAVLKQKISVKFDAVIGYKMKAQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted
Function
- Function:
- Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
- Catalytic Activity:
- 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
- Active Site:
- ACT_SITE 185 185 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular region
intracellular membrane-bounded organelle
lipid particle
estradiol 17-beta-dehydrogenase activity
steroid dehydrogenase activity
androgen catabolic process
estrogen biosynthetic process
small molecule metabolic process
steroid metabolic process - Gene Ontology Biological Process:
- androgen catabolic process
estrogen biosynthetic process
small molecule metabolic process
steroid metabolic process - Gene Ontology Molecular Function:
- estradiol 17-beta-dehydrogenase activity
steroid dehydrogenase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular region
intracellular membrane-bounded organelle
lipid particle - Keywords:
- 3D-structure
Complete proteome
Lipid biosynthesis
Lipid metabolism
NADP
Oxidoreductase
Reference proteome
Secreted
Signal
Steroid biosynthesis