Names & Taxonomy

Uniprot ID:
Q8N9I0
Entry Name:
SYT2_HUMAN
Status:
reviewed
Protein Names:
Synaptotagmin-2 (Synaptotagmin II) (SytII)
Gene Names:
SYT2
Gene Names Primary:
SYT2
Organism:
Homo sapiens (Human)

Structure

Length:
419
Sequence:
MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane

Function

Function:
Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Cross Reference Drug Bank:
DB00042
Gene Ontology Go:
cell junction
chromaffin granule membrane
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
synaptic vesicle membrane
calcium ion binding
calcium-dependent phospholipid binding
clathrin binding
inositol 1,3,4,5 tetrakisphosphate binding
syntaxin binding
neurotransmitter secretion
positive regulation of dendrite extension
synaptic vesicle endocytosis
Gene Ontology Biological Process:
neurotransmitter secretion
positive regulation of dendrite extension
synaptic vesicle endocytosis
Gene Ontology Molecular Function:
calcium-dependent phospholipid binding
calcium ion binding
clathrin binding
inositol 1,3,4,5 tetrakisphosphate binding
syntaxin binding
Gene Ontology Cellular Component:
cell junction
chromaffin granule membrane
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
synaptic vesicle membrane
Keywords:
Calcium
Cell junction
Complete proteome
Congenital myasthenic syndrome
Cytoplasmic vesicle
Differentiation
Disease mutation
Glycoprotein
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Synapse
Transmembrane
Transmembrane helix

Publication

PubMed ID:
14702039 15489334 11381094 19234194 23999003 25192047