Names & Taxonomy
- Uniprot ID:
- Q8N9I0
- Entry Name:
- SYT2_HUMAN
- Status:
- reviewed
- Protein Names:
- Synaptotagmin-2 (Synaptotagmin II) (SytII)
- Gene Names:
- SYT2
- Gene Names Primary:
- SYT2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 419
- Sequence:
- MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Function
- Function:
- Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cross Reference Drug Bank:
- DB00042
- Gene Ontology Go:
- cell junction
chromaffin granule membrane
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
synaptic vesicle membrane
calcium ion binding
calcium-dependent phospholipid binding
clathrin binding
inositol 1,3,4,5 tetrakisphosphate binding
syntaxin binding
neurotransmitter secretion
positive regulation of dendrite extension
synaptic vesicle endocytosis - Gene Ontology Biological Process:
- neurotransmitter secretion
positive regulation of dendrite extension
synaptic vesicle endocytosis - Gene Ontology Molecular Function:
- calcium-dependent phospholipid binding
calcium ion binding
clathrin binding
inositol 1,3,4,5 tetrakisphosphate binding
syntaxin binding - Gene Ontology Cellular Component:
- cell junction
chromaffin granule membrane
integral component of membrane
intracellular membrane-bounded organelle
plasma membrane
synaptic vesicle membrane - Keywords:
- Calcium
Cell junction
Complete proteome
Congenital myasthenic syndrome
Cytoplasmic vesicle
Differentiation
Disease mutation
Glycoprotein
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Synapse
Transmembrane
Transmembrane helix