Names & Taxonomy
- Uniprot ID:
- A0A024R244
- Entry Name:
- A0A024R244_HUMAN
- Status:
- unreviewed
- Protein Names:
- Tyrosine-protein kinase (EC 2.7.10.2)
- Gene Names:
- SYK hCG_29698
- Gene Names Orf:
- hCG_29698
- Gene Names Primary:
- SYK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 635
- Sequence:
- MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Function
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 494 494 Proton acceptor.
- Gene Ontology Go:
- B cell receptor complex
early phagosome
ATP binding
non-membrane spanning protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
activation of JUN kinase activity
B cell receptor signaling pathway
beta selection
blood vessel morphogenesis
cellular response to low-density lipoprotein particle stimulus
cellular response to molecule of fungal origin
defense response to bacterium
enzyme linked receptor protein signaling pathway
innate immune response
integrin-mediated signaling pathway
leukotriene biosynthetic process
lymph vessel development
macrophage activation involved in immune response
neutrophil activation involved in immune response
peptidyl-serine phosphorylation
positive regulation of alpha-beta T cell differentiation
positive regulation of alpha-beta T cell proliferation
positive regulation of B cell differentiation
positive regulation of bone resorption
positive regulation of calcium-mediated signaling
positive regulation of cell adhesion mediated by integrin
positive regulation of cytokine secretion
positive regulation of gamma-delta T cell differentiation
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of interleukin-3 biosynthetic process
positive regulation of mast cell degranulation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of receptor internalization
positive regulation of type I interferon production
protein autophosphorylation
receptor internalization
regulation of arachidonic acid secretion
regulation of ERK1 and ERK2 cascade
regulation of neutrophil degranulation
regulation of phagocytosis
regulation of platelet aggregation
regulation of superoxide anion generation
serotonin secretion by platelet - Gene Ontology Biological Process:
- activation of JUN kinase activity
B cell receptor signaling pathway
beta selection
blood vessel morphogenesis
cellular response to low-density lipoprotein particle stimulus
cellular response to molecule of fungal origin
defense response to bacterium
enzyme linked receptor protein signaling pathway
innate immune response
integrin-mediated signaling pathway
leukotriene biosynthetic process
lymph vessel development
macrophage activation involved in immune response
neutrophil activation involved in immune response
peptidyl-serine phosphorylation
positive regulation of alpha-beta T cell differentiation
positive regulation of alpha-beta T cell proliferation
positive regulation of B cell differentiation
positive regulation of bone resorption
positive regulation of calcium-mediated signaling
positive regulation of cell adhesion mediated by integrin
positive regulation of cytokine secretion
positive regulation of gamma-delta T cell differentiation
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
positive regulation of interleukin-3 biosynthetic process
positive regulation of mast cell degranulation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of receptor internalization
positive regulation of type I interferon production
protein autophosphorylation
receptor internalization
regulation of arachidonic acid secretion
regulation of ERK1 and ERK2 cascade
regulation of neutrophil degranulation
regulation of phagocytosis
regulation of platelet aggregation
regulation of superoxide anion generation
serotonin secretion by platelet - Gene Ontology Molecular Function:
- ATP binding
non-membrane spanning protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity - Gene Ontology Cellular Component:
- B cell receptor complex
early phagosome - Keywords:
- ATP-binding
Kinase
Nucleotide-binding
Transferase
Tyrosine-protein kinase
Publication
- PubMed ID:
- 11181995