Names & Taxonomy
- Uniprot ID:
- Q8IVW8
- Entry Name:
- SPNS2_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein spinster homolog 2
- Gene Names:
- SPNS2
- Gene Names Primary:
- SPNS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 549
- Sequence:
- MMCLECASAAAGGAEEEEADAERRRRRRGAQRGAGGSGCCGARGAGGAGVSAAGDEVQTLSGSVRRAPTGPPGTPGTPGCAATAKGPGAQQPKPASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGDQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFVSDRARAEQQVNQLAMPPASVKV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.
- Gene Ontology Go:
- integral component of membrane
lysosomal membrane
vesicle
sphingolipid transporter activity
B cell homeostasis
bone development
locomotion
lymph node development
lymphocyte migration
regulation of eye pigmentation
regulation of humoral immune response
sphingolipid metabolic process
sphingosine-1-phosphate signaling pathway
T cell homeostasis
transmembrane transport - Gene Ontology Biological Process:
- B cell homeostasis
bone development
locomotion
lymph node development
lymphocyte migration
regulation of eye pigmentation
regulation of humoral immune response
sphingolipid metabolic process
sphingosine-1-phosphate signaling pathway
T cell homeostasis
transmembrane transport - Gene Ontology Molecular Function:
- sphingolipid transporter activity
- Gene Ontology Cellular Component:
- integral component of membrane
lysosomal membrane
vesicle - Keywords:
- Complete proteome
Lipid transport
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport