Names & Taxonomy
- Uniprot ID:
- Q8IVS2
- Entry Name:
- FABD_HUMAN
- Status:
- reviewed
- Protein Names:
- Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase)
- Gene Names:
- MCAT MT
- Gene Names Primary:
- MCAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 390
- Sequence:
- MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIRAEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIENPVCEVSNYLFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAVDIKKPLVSVYSNVHAHRYRHPGHIHKLLAQQLVSPVKWEQTMHAIYERKKGRGFPQTFEVGPGRQLGAILKSCNMQAWKSYSAVDVLQTLEHVDLDPQEPPR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias.
- Pathway:
- Lipid metabolism; fatty acid biosynthesis.
- Catalytic Activity:
- Malonyl-CoA + an = CoA + a malonyl-.
- Active Site:
- ACT_SITE 153 153
- Gene Ontology Go:
- mitochondrion
S-malonyltransferase activity
poly(A) RNA binding
transferase activity
fatty acid biosynthetic process
metabolic process - Gene Ontology Biological Process:
- fatty acid biosynthetic process
metabolic process - Gene Ontology Molecular Function:
- S-malonyltransferase activity
poly(A) RNA binding
transferase activity - Gene Ontology Cellular Component:
- mitochondrion
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Mitochondrion
Polymorphism
Reference proteome
Transferase
Transit peptide