Names & Taxonomy
- Uniprot ID:
- Q8IVL6
- Entry Name:
- P3H3_HUMAN
- Status:
- reviewed
- Protein Names:
- Prolyl 3-hydroxylase 3 (EC 1.14.11.7) (Leprecan-like protein 2) (Protein B)
- Gene Names:
- P3H3 LEPREL2
- Gene Names Primary:
- P3H3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 736
- Sequence:
- MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAAGAWAPAVALLREALRSQAALGRVRLDCGASCAADPGAALPAVLLGAPEPDSGPGPTQGSWERQLLRAALRRADCLTQCAARRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAAAAAHTFFVANPMHLQMREDMAKYRRMSGVRPQSFRDLETPPHWAAYDTGLELLGRQEAGLALPRLEEALQGSLAQMESCRADCEGPEEQQGAEEEEDGAASQGGLYEAIAGHWIQVLQCRQRCVGETATRPGRSFPVPDFLPNQLRRLHEAHAQVGNLSQAIENVLSVLLFYPEDEAAKRALNQYQAQLGEPRPGLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDPWTPAALIPEALREKLREDQEKRPWDHEPVKPKPLTYWKDVLLLEGVTLTQDSRQLNGSERAVLDGLLTPAECGVLLQLAKDAAGAGARSGYRGRRSPHTPHERFEGLTVLKAAQLARAGTVGSQGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFQGGDLFFTEPNALTVTARVRPRCGRLVAFSSGVENPHGVWAVTRGRRCALALWHTWAPEHREQEWIEAKELLQESQEEEEEEEEEMPSKDPSPEPPSRRHQRVQDKTGRAPRVREEL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum
Function
- Function:
- Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly-sequences in collagens, especially types IV and V.
- Catalytic Activity:
- L-proline- + 2-oxoglutarate + O(2) = trans-3-hydroxy-L-proline- + succinate + CO(2).
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Active Site:
- ACT_SITE 666 666
- Cross Reference Drug Bank:
- DB00172 DB00139 DB00126
- Gene Ontology Go:
- endoplasmic reticulum lumen
iron ion binding
L-ascorbic acid binding
procollagen-proline 3-dioxygenase activity
extracellular matrix organization
negative regulation of cell proliferation - Gene Ontology Biological Process:
- extracellular matrix organization
negative regulation of cell proliferation - Gene Ontology Molecular Function:
- iron ion binding
L-ascorbic acid binding
procollagen-proline 3-dioxygenase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum lumen
- Keywords:
- Alternative splicing
Coiled coil
Complete proteome
Dioxygenase
Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Oxidoreductase
Polymorphism
Reference proteome
Repeat
Signal
TPR repeat
Vitamin C