Names & Taxonomy
- Uniprot ID:
- Q8IUX7
- Entry Name:
- AEBP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein)
- Gene Names:
- AEBP1 ACLP
- Gene Names Primary:
- AEBP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1158
- Sequence:
- MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEKGKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEESETETYTEVVTEFGTEVEPEFGTKVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATGQAFPFTTVETYTVNFGDF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Secreted
Function
- Function:
- May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
extracellular space
nucleus
carboxypeptidase activity
metallocarboxypeptidase activity
RNA polymerase II regulatory region sequence-specific DNA binding
serine-type carboxypeptidase activity
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
zinc ion binding
muscle organ development
negative regulation of transcription from RNA polymerase II promoter
peptide metabolic process
protein processing
skeletal system development
transcription, DNA-templated - Gene Ontology Biological Process:
- muscle organ development
negative regulation of transcription from RNA polymerase II promoter
peptide metabolic process
protein processing
skeletal system development
transcription, DNA-templated - Gene Ontology Molecular Function:
- carboxypeptidase activity
metallocarboxypeptidase activity
RNA polymerase II regulatory region sequence-specific DNA binding
serine-type carboxypeptidase activity
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
extracellular space
nucleus - Keywords:
- Alternative splicing
Calmodulin-binding
Complete proteome
Cytoplasm
DNA-binding
Glycoprotein
Nucleus
Polymorphism
Reference proteome
Repressor
Secreted
Signal
Transcription
Transcription regulation