Names & Taxonomy

Uniprot ID:
Q8IUX7
Entry Name:
AEBP1_HUMAN
Status:
reviewed
Protein Names:
Adipocyte enhancer-binding protein 1 (AE-binding protein 1) (Aortic carboxypeptidase-like protein)
Gene Names:
AEBP1 ACLP
Gene Names Primary:
AEBP1
Organism:
Homo sapiens (Human)

Structure

Length:
1158
Sequence:
MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSELEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAREHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPPEEKAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDEEKEELKKPKKEDSSPKEETDKWAVEKGKDHKEPRKGEELEEEWTPTEKVKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYSYYAQNEVVATDDLDFRHHSYKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDEDEVSEAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTGTINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYDIGATQCNFILARSNWKRIREIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLRAQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEESETETYTEVVTEFGTEVEPEFGTKVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATGQAFPFTTVETYTVNFGDF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Secreted

Function

Function:
May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
Gene Ontology Go:
cytoplasm
extracellular exosome
extracellular space
nucleus
carboxypeptidase activity
metallocarboxypeptidase activity
RNA polymerase II regulatory region sequence-specific DNA binding
serine-type carboxypeptidase activity
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
zinc ion binding
muscle organ development
negative regulation of transcription from RNA polymerase II promoter
peptide metabolic process
protein processing
skeletal system development
transcription, DNA-templated
Gene Ontology Biological Process:
muscle organ development
negative regulation of transcription from RNA polymerase II promoter
peptide metabolic process
protein processing
skeletal system development
transcription, DNA-templated
Gene Ontology Molecular Function:
carboxypeptidase activity
metallocarboxypeptidase activity
RNA polymerase II regulatory region sequence-specific DNA binding
serine-type carboxypeptidase activity
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription corepressor activity
transcription factor activity, sequence-specific DNA binding
zinc ion binding
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
extracellular space
nucleus
Keywords:
Alternative splicing
Calmodulin-binding
Complete proteome
Cytoplasm
DNA-binding
Glycoprotein
Nucleus
Polymorphism
Reference proteome
Repressor
Secreted
Signal
Transcription
Transcription regulation

Publication

PubMed ID:
9624159 14702039 12690205 15489334 8920928 19159218 24275569