Names & Taxonomy
- Uniprot ID:
- Q86YT5
- Entry Name:
- S13A5_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 13 member 5 (Na(+)/citrate cotransporter) (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter)
- Gene Names:
- SLC13A5 NACT
- Gene Names Primary:
- SLC13A5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 568
- Sequence:
- MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNFRSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWANVTHIET
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
citrate transmembrane transporter activity
sodium:dicarboxylate symporter activity
succinate transmembrane transporter activity
citrate transport
transmembrane transport
tricarboxylic acid transmembrane transport - Gene Ontology Biological Process:
- citrate transport
transmembrane transport
tricarboxylic acid transmembrane transport - Gene Ontology Molecular Function:
- citrate transmembrane transporter activity
sodium:dicarboxylate symporter activity
succinate transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Ion transport
Membrane
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport