Names & Taxonomy

Uniprot ID:
Q86WA6
Entry Name:
BPHL_HUMAN
Status:
reviewed
Protein Names:
Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA)
Gene Names:
BPHL MCNAA
Gene Names Primary:
BPHL
Organism:
Homo sapiens (Human)

Structure

Length:
291
Sequence:
MVAVLGGRGVLRLRLLLSALKPGIHVPRAGPAAAFGTSVTSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERDAKDAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFKHLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFADEFNKLAEDFLQ
Proteomes:
UP000005640

Function

Function:
Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
Active Site:
ACT_SITE 139 139 Nucleophile.
Gene Ontology Go:
extracellular exosome
mitochondrial outer membrane
mitochondrion
hydrolase activity
cellular amino acid metabolic process
response to toxic substance
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular amino acid metabolic process
response to toxic substance
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
hydrolase activity
Gene Ontology Cellular Component:
extracellular exosome
mitochondrial outer membrane
mitochondrion
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Hydrolase
Reference proteome
Signal

Publication

PubMed ID:
7759552 14574404 15489334 2393862 12732646 9721218 15832508 19608861 21269460 25944712 18256025