Names & Taxonomy
- Uniprot ID:
- Q86WA6
- Entry Name:
- BPHL_HUMAN
- Status:
- reviewed
- Protein Names:
- Valacyclovir hydrolase (VACVase) (Valacyclovirase) (EC 3.1.-.-) (Biphenyl hydrolase-like protein) (Biphenyl hydrolase-related protein) (Bph-rp) (Breast epithelial mucin-associated antigen) (MCNAA)
- Gene Names:
- BPHL MCNAA
- Gene Names Primary:
- BPHL
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 291
- Sequence:
- MVAVLGGRGVLRLRLLLSALKPGIHVPRAGPAAAFGTSVTSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERDAKDAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFKHLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFADEFNKLAEDFLQ
- Proteomes:
- UP000005640
Function
- Function:
- Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
- Active Site:
- ACT_SITE 139 139 Nucleophile.
- Gene Ontology Go:
- extracellular exosome
mitochondrial outer membrane
mitochondrion
hydrolase activity
cellular amino acid metabolic process
response to toxic substance
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular amino acid metabolic process
response to toxic substance
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- hydrolase activity
- Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial outer membrane
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Hydrolase
Reference proteome
Signal