Names & Taxonomy
- Uniprot ID:
- Q7Z7B1
- Entry Name:
- PIGW_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylinositol-glycan biosynthesis class W protein (PIG-W) (EC 2.3.-.-)
- Gene Names:
- PIGW
- Gene Names Primary:
- PIGW
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 504
- Sequence:
- MSEKQMKEAFVSNLNGTTVLEITQGLCFPAFCILCRGFLIIFSQYLCSFSPTWKTRFLTDFVVLIVPMVATLTIWASFILLELLGVIIFGAGLLYQIYRRRTCYARLPFLKILEKFLNISLESEYNPAISCFRVITSAFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFVFGSAMVCLEVRRRKYMEGSKLHYFTNSLYSVWPLVFLGIGRLAIIKSIGYQEHLTEYGVHWNFFFTIIVVKLITPLLLIIFPLNKSWIIALGITVLYQLALDFTSLKRLILYGTDGSGTRVGLLNANREGIISTLGYVAIHMAGVQTGLYMHKNRSHIKDLIKVACFLLLAAISLFISLYVVQVNVEAVSRRMANLAFCIWIVASSLILLSSLLLGDIILSFAKFLIKGALVPCSWKLIQSPVTNKKHSESLVPEAERMEPSLCLITALNRKQLIFFLLSNITTGLINLMVDTLHSSTLWALFVVNLYMFSNCLIVYVLYLQDKTVQFW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057). Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity).
- Pathway:
- Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
transferase activity, transferring acyl groups
C-terminal protein lipidation
cellular protein metabolic process
GPI anchor metabolic process
post-translational protein modification
preassembly of GPI anchor in ER membrane
protein localization to plasma membrane - Gene Ontology Biological Process:
- cellular protein metabolic process
C-terminal protein lipidation
GPI anchor metabolic process
post-translational protein modification
preassembly of GPI anchor in ER membrane
protein localization to plasma membrane - Gene Ontology Molecular Function:
- transferase activity, transferring acyl groups
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Acyltransferase
Complete proteome
Disease mutation
Endoplasmic reticulum
GPI-anchor biosynthesis
Glycoprotein
Membrane
Mental retardation
Reference proteome
Transferase
Transmembrane
Transmembrane helix