Names & Taxonomy
- Uniprot ID:
- Q7Z4W1
- Entry Name:
- DCXR_HUMAN
- Status:
- reviewed
- Protein Names:
- L-xylulose reductase (XR) (EC 1.1.1.10) (Carbonyl reductase II) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Short chain dehydrogenase/reductase family 20C member 1) (Sperm surface protein P34H)
- Gene Names:
- DCXR SDR20C1
- Gene Names Primary:
- DCXR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 244
- Sequence:
- MELFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPGIEPVCVDLGDWEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTGSTLPVEGGFWAC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules.
- Catalytic Activity:
- Xylitol + NADP(+) = L-xylulose + NADPH.
- Active Site:
- ACT_SITE 149 149 Proton acceptor.
- Cross Reference Drug Bank:
- DB02325
- Gene Ontology Go:
- brush border
cytoplasmic microtubule
extracellular exosome
microvillus
nucleus
plasma membrane
L-xylulose reductase (NADP+) activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
carbohydrate metabolic process
D-xylose metabolic process
glucose metabolic process
glucuronate catabolic process to xylulose 5-phosphate
NADP metabolic process
oxidation-reduction process
protein homotetramerization
small molecule metabolic process
xylulose metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
D-xylose metabolic process
glucose metabolic process
glucuronate catabolic process to xylulose 5-phosphate
NADP metabolic process
oxidation-reduction process
protein homotetramerization
small molecule metabolic process
xylulose metabolic process - Gene Ontology Molecular Function:
- L-xylulose reductase (NADP+) activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor - Gene Ontology Cellular Component:
- brush border
cytoplasmic microtubule
extracellular exosome
microvillus
nucleus
plasma membrane - Keywords:
- 3D-structure
Acetylation
Carbohydrate metabolism
Complete proteome
Direct protein sequencing
Glucose metabolism
Membrane
NADP
Oxidoreductase
Phosphoprotein
Reference proteome
Xylose metabolism