Names & Taxonomy
- Uniprot ID:
- Q7RTP0
- Entry Name:
- NIPA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Magnesium transporter NIPA1 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 1) (Spastic paraplegia 6 protein)
- Gene Names:
- NIPA1 SPG6
- Gene Names Primary:
- NIPA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 329
- Sequence:
- MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGSTFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALGVPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPVFVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILHNNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLASAILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity).
- Gene Ontology Go:
- early endosome
integral component of membrane
plasma membrane
magnesium ion transmembrane transporter activity
magnesium ion transport
transmembrane transport - Gene Ontology Biological Process:
- magnesium ion transport
transmembrane transport - Gene Ontology Molecular Function:
- magnesium ion transmembrane transporter activity
- Gene Ontology Cellular Component:
- early endosome
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Endosome
Hereditary spastic paraplegia
Ion transport
Magnesium
Membrane
Neurodegeneration
Reference proteome
Transmembrane
Transmembrane helix
Transport