Names & Taxonomy
- Uniprot ID:
- Q7LG56
- Entry Name:
- RIR2B_HUMAN
- Status:
- reviewed
- Protein Names:
- Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)
- Gene Names:
- RRM2B P53R2
- Gene Names Primary:
- RRM2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 351
- Sequence:
- MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFSKVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.
Function
- Function:
- Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
- Pathway:
- Genetic information processing; DNA replication.
- Catalytic Activity:
- 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin.
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Active Site:
- ACT_SITE 138 138
- Cross Reference Drug Bank:
- DB00242
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleoplasm
ribonucleoside-diphosphate reductase complex
metal ion binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
deoxyribonucleoside diphosphate metabolic process
deoxyribonucleoside triphosphate metabolic process
deoxyribonucleotide biosynthetic process
DNA repair
gene expression
kidney development
mitochondrial DNA replication
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
renal system process
response to amine
response to oxidative stress
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- deoxyribonucleoside diphosphate metabolic process
deoxyribonucleoside triphosphate metabolic process
deoxyribonucleotide biosynthetic process
DNA repair
gene expression
kidney development
mitochondrial DNA replication
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
renal system process
response to amine
response to oxidative stress
small molecule metabolic process
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- metal ion binding
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleoplasm
ribonucleoside-diphosphate reductase complex - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
DNA damage
DNA repair
DNA replication
Disease mutation
Iron
Metal-binding
Neuropathy
Nucleus
Oxidoreductase
Polymorphism
Progressive external ophthalmoplegia
Reference proteome - Interacts With:
- O43929