Names & Taxonomy
- Uniprot ID:
- Q7L5Y9
- Entry Name:
- MAEA_HUMAN
- Status:
- reviewed
- Protein Names:
- Macrophage erythroblast attacher (Cell proliferation-inducing gene 5 protein) (Erythroblast macrophage protein) (Human lung cancer oncogene 10 protein) (HLC-10)
- Gene Names:
- MAEA EMP HLC10 PIG5
- Gene Names Orf:
- HLC10 PIG5
- Gene Names Primary:
- MAEA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 396
- Sequence:
- MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSGCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus matrix
Function
- Function:
- Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
- Cross Reference Drug Bank:
- DB05389
- Gene Ontology Go:
- actomyosin contractile ring
cytoplasm
cytoskeleton
integral component of plasma membrane
nuclear matrix
nucleus
spindle
actin binding
cell adhesion
cell cycle
cell division
cytoskeleton organization
enucleate erythrocyte development
erythrocyte maturation
negative regulation of myeloid cell apoptotic process
regulation of mitotic cell cycle - Gene Ontology Biological Process:
- cell adhesion
cell cycle
cell division
cytoskeleton organization
enucleate erythrocyte development
erythrocyte maturation
negative regulation of myeloid cell apoptotic process
regulation of mitotic cell cycle - Gene Ontology Molecular Function:
- actin binding
- Gene Ontology Cellular Component:
- actomyosin contractile ring
cytoplasm
cytoskeleton
integral component of plasma membrane
nuclear matrix
nucleus
spindle - Keywords:
- Actin-binding
Alternative splicing
Cell cycle
Cell division
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Erythrocyte maturation
Membrane
Nucleus
Polymorphism
Reference proteome