Names & Taxonomy

Uniprot ID:
Q70Z44
Entry Name:
5HT3D_HUMAN
Status:
reviewed
Protein Names:
5-hydroxytryptamine receptor 3D (5-HT3-D) (5-HT3D) (Serotonin receptor 3D)
Gene Names:
HTR3D
Gene Names Primary:
HTR3D
Organism:
Homo sapiens (Human)

Structure

Length:
454
Sequence:
MQKHSPGPPALALLSQSLLTTGNGDTLIINCPGFGQHRVDPAAFQAVFDRKAIGPVTNYSVATHVNISFTLSAIWNCYSRIHTFNCHHARPWHNQFVQWNPDECGGIKKSGMATENLWLSDVFIEESVDQTPAGLMASMSIVKATSNTISQCGWSASANWTPSISPSMDRARAWRRMSRSFQIHHRTSFRTRREWVLLGIQKRTIKVTVATNQYEQAIFHVAIRRRCRPSPYVVNFLVPSGILIAIDALSFYLPLESGNCAPFKMTVLLGYSVFLLMMNDLLPATSTSSHASLVAPLALMQTPLPAGVYFALCLSLMVGSLLETIFITHLLHVATTQPLPLPRWLHSLLLHCTGQGRCCPTAPQKGNKGPGLTPTHLPGVKEPEVSAGQMPGPGEAELTGGSEWTRAQREHEAQKQHSVELWVQFSHAMDALLFRLYLLFMASSIITVICLWNT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Cross Reference Drug Bank:
DB01049 DB00898
Gene Ontology Go:
integral component of membrane
plasma membrane
G-protein coupled serotonin receptor activity
serotonin-activated cation-selective channel activity
cation transmembrane transport
ion transmembrane transport
serotonin receptor signaling pathway
transmembrane transport
Gene Ontology Biological Process:
cation transmembrane transport
ion transmembrane transport
serotonin receptor signaling pathway
transmembrane transport
Gene Ontology Molecular Function:
G-protein coupled serotonin receptor activity
serotonin-activated cation-selective channel activity
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
Alternative splicing
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Ligand-gated ion channel
Membrane
Polymorphism
Receptor
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport
Interacts With:
P46098

Publication

PubMed ID:
12801637 17392525 16641997 15489334