Names & Taxonomy
- Uniprot ID:
- Q6ZQN7
- Entry Name:
- SO4C1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier organic anion transporter family member 4C1 (OATP-H) (Organic anion transporter M1) (OATP-M1) (Solute carrier family 21 member 20)
- Gene Names:
- SLCO4C1 OATP4C1 OATPX SLC21A20
- Gene Names Primary:
- SLCO4C1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 724
- Sequence:
- MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENSQPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCNTPGGFLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSLFVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSCTSSTSSLSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSILGPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSCFPKHLPGTAEIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTSSEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTCKNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCSRSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAETFGFEAKAGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRLLGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFFNGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKIVKEG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Basolateral cell membrane
Function
- Function:
- Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.8 uM for digoxin
- Cross Reference Drug Bank:
- DB00509 DB01396 DB00390 DB00451 DB00279 DB01583 DB00563 DB01092 DB06335
- Gene Ontology Go:
- basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
sodium-independent organic anion transmembrane transporter activity
cell differentiation
multicellular organism development
sodium-independent organic anion transport
spermatogenesis
transmembrane transport - Gene Ontology Biological Process:
- cell differentiation
multicellular organism development
sodium-independent organic anion transport
spermatogenesis
transmembrane transport - Gene Ontology Molecular Function:
- sodium-independent organic anion transmembrane transporter activity
- Gene Ontology Cellular Component:
- basolateral plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Ion transport
Membrane
Phosphoprotein
Reference proteome
Spermatogenesis
Transmembrane
Transmembrane helix
Transport