Names & Taxonomy
- Uniprot ID:
- Q6ZNC8
- Entry Name:
- MBOA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Lysophospholipid acyltransferase 1 (LPLAT 1) (EC 2.3.1.-) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 1) (O-acyltransferase domain-containing protein 1)
- Gene Names:
- MBOAT1 OACT1
- Gene Names Primary:
- MBOAT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 495
- Sequence:
- MAAEPQPSSLSYRTTGSTYLHPLSELLGIPLDQVNFVVCQLVALFAAFWFRIYLRPGTTSSDVRHAVATIFGIYFVIFCFGWYSVHLFVLVLMCYAIMVTASVSNIHRYSFFVAMGYLTICHISRIYIFHYGILTTDFSGPLMIVTQKITTLAFQVHDGLGRRAEDLSAEQHRLAIKVKPSFLEYLSYLLNFMSVIAGPCNNFKDYIAFIEGKHIHMKLLEVNWKRKGFHSLPEPSPTGAVIHKLGITLVSLLLFLTLTKTFPVTCLVDDWFVHKASFPARLCYLYVVMQASKPKYYFAWTLADAVNNAAGFGFSGVDKNGNFCWDLLSNLNIWKIETATSFKMYLENWNIQTATWLKCVCYQRVPWYPTVLTFILSALWHGVYPGYYFTFLTGILVTLAARAVRNNYRHYFLSSRALKAVYDAGTWAVTQLAVSYTVAPFVMLAVEPTISLYKSMYFYLHIISLLIILFLPMKPQAHTQRRPQTLNSINKRKTD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.
- Pathway:
- Lipid metabolism; phospholipid metabolism.
- Catalytic Activity:
- Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylserine.
- Enzyme Regulation:
- ENZYME REGULATION: Partially inhibited by thimerosal.
- Active Site:
- ACT_SITE 350 350
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of membrane
transferase activity, transferring acyl groups other than amino-acyl groups
glycerophospholipid biosynthetic process
phosphatidylethanolamine acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- glycerophospholipid biosynthetic process
phosphatidylethanolamine acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- transferase activity, transferring acyl groups other than amino-acyl groups
- Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Acyltransferase
Alternative splicing
Complete proteome
Lipid biosynthesis
Lipid metabolism
Membrane
Phospholipid biosynthesis
Phospholipid metabolism
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix