Names & Taxonomy
- Uniprot ID:
- Q6VVX0
- Entry Name:
- CP2R1_HUMAN
- Status:
- reviewed
- Protein Names:
- Vitamin D 25-hydroxylase (EC 1.14.14.24) (Cytochrome P450 2R1)
- Gene Names:
- CYP2R1
- Gene Names Primary:
- CYP2R1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 501
- Sequence:
- MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Function
- Function:
- Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
- Catalytic Activity:
- Calciol + O(2) + = calcidiol + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.67 uM for vitamin D(2)
- Cross Reference Drug Bank:
- DB00169 DB00153
- Gene Ontology Go:
- endoplasmic reticulum membrane
heme binding
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
steroid hydroxylase activity
vitamin D3 25-hydroxylase activity
fat-soluble vitamin metabolic process
response to cesium ion
response to ionizing radiation
small molecule metabolic process
vitamin D metabolic process
vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- fat-soluble vitamin metabolic process
response to cesium ion
response to ionizing radiation
small molecule metabolic process
vitamin D metabolic process
vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- heme binding
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
steroid hydroxylase activity
vitamin D3 25-hydroxylase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
- Keywords:
- 3D-structure
Complete proteome
Disease mutation
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
NADP
Oxidoreductase
Reference proteome