Names & Taxonomy

Uniprot ID:
Q6VVX0
Entry Name:
CP2R1_HUMAN
Status:
reviewed
Protein Names:
Vitamin D 25-hydroxylase (EC 1.14.14.24) (Cytochrome P450 2R1)
Gene Names:
CYP2R1
Gene Names Primary:
CYP2R1
Organism:
Homo sapiens (Human)

Structure

Length:
501
Sequence:
MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Function

Function:
Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
Catalytic Activity:
Calciol + O(2) + = calcidiol + + H(2)O.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.67 uM for vitamin D(2)
Cross Reference Drug Bank:
DB00169 DB00153
Gene Ontology Go:
endoplasmic reticulum membrane
heme binding
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
steroid hydroxylase activity
vitamin D3 25-hydroxylase activity
fat-soluble vitamin metabolic process
response to cesium ion
response to ionizing radiation
small molecule metabolic process
vitamin D metabolic process
vitamin metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
fat-soluble vitamin metabolic process
response to cesium ion
response to ionizing radiation
small molecule metabolic process
vitamin D metabolic process
vitamin metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
heme binding
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
steroid hydroxylase activity
vitamin D3 25-hydroxylase activity
Gene Ontology Cellular Component:
endoplasmic reticulum membrane
Keywords:
3D-structure
Complete proteome
Disease mutation
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
NADP
Oxidoreductase
Reference proteome

Publication

PubMed ID:
12867411 15465040 15489334 18511070 15128933 25942481