Names & Taxonomy
- Uniprot ID:
- Q6PCB7
- Entry Name:
- S27A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Long-chain fatty acid transport protein 1 (FATP-1) (Fatty acid transport protein 1) (EC 6.2.1.-) (Solute carrier family 27 member 1)
- Gene Names:
- SLC27A1 ACSVL5 FATP1
- Gene Names Primary:
- SLC27A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 646
- Sequence:
- MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity).
- Gene Ontology Go:
- caveola
endoplasmic reticulum
integral component of membrane
membrane
mitochondrial inner membrane
plasma membrane
fatty acid transporter activity
long-chain fatty acid-CoA ligase activity
nucleotide binding
very long-chain fatty acid-CoA ligase activity
adiponectin-activated signaling pathway
cardiolipin biosynthetic process
cellular lipid metabolic process
long-chain fatty acid transport
medium-chain fatty acid transport
negative regulation of phospholipid biosynthetic process
phosphatidic acid biosynthetic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phosphatidylglycerol biosynthetic process
phosphatidylinositol biosynthetic process
phosphatidylserine biosynthetic process
positive regulation of heat generation
positive regulation of protein serine/threonine kinase activity
response to cold
response to insulin
small molecule metabolic process
transmembrane transport - Gene Ontology Biological Process:
- adiponectin-activated signaling pathway
cardiolipin biosynthetic process
cellular lipid metabolic process
long-chain fatty acid transport
medium-chain fatty acid transport
negative regulation of phospholipid biosynthetic process
phosphatidic acid biosynthetic process
phosphatidylcholine biosynthetic process
phosphatidylethanolamine biosynthetic process
phosphatidylglycerol biosynthetic process
phosphatidylinositol biosynthetic process
phosphatidylserine biosynthetic process
positive regulation of heat generation
positive regulation of protein serine/threonine kinase activity
response to cold
response to insulin
small molecule metabolic process
transmembrane transport - Gene Ontology Molecular Function:
- fatty acid transporter activity
long-chain fatty acid-CoA ligase activity
nucleotide binding
very long-chain fatty acid-CoA ligase activity - Gene Ontology Cellular Component:
- caveola
endoplasmic reticulum
integral component of membrane
membrane
mitochondrial inner membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Fatty acid metabolism
Ligase
Lipid metabolism
Lipid transport
Membrane
Nucleotide-binding
Reference proteome
Transmembrane
Transmembrane helix
Transport