Names & Taxonomy
- Uniprot ID:
- Q6NUS8
- Entry Name:
- UD3A1_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 3A1 (UDPGT 3A1) (EC 2.4.1.17)
- Gene Names:
- UGT3A1
- Gene Names Primary:
- UGT3A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 523
- Sequence:
- MVGQRVLLLVAFLLSGVLLSEAAKILTISTLGGSHYLLLDRVSQILQEHGHNVTMLHQSGKFLIPDIKEEEKSYQVIRWFSPEDHQKRIKKHFDSYIETALDGRKESEALVKLMEIFGTQCSYLLSRKDIMDSLKNENYDLVFVEAFDFCSFLIAEKLVKPFVAILPTTFGSLDFGLPSPLSYVPVFPSLLTDHMDFWGRVKNFLMFFSFSRSQWDMQSTFDNTIKEHFPEGSRPVLSHLLLKAELWFVNSDFAFDFARPLLPNTVYIGGLMEKPIKPVPQDLDNFIANFGDAGFVLVAFGSMLNTHQSQEVLKKMHNAFAHLPQGVIWTCQSSHWPRDVHLATNVKIVDWLPQSDLLAHPSIRLFVTHGGQNSVMEAIRHGVPMVGLPVNGDQHGNMVRVVAKNYGVSIRLNQVTADTLTLTMKQVIEDKRYKSAVVAASVILHSQPLSPAQRLVGWIDHILQTGGATHLKPYAFQQPWHEQYLIDVFVFLLGLTLGTMWLCGKLLGVVARWLRGARKVKKT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Gene Ontology Go:
- integral component of membrane
UDP-N-acetylglucosamine transferase complex
glucuronosyltransferase activity
UDP-glycosyltransferase activity
flavonoid biosynthetic process
flavonoid glucuronidation - Gene Ontology Biological Process:
- flavonoid biosynthetic process
flavonoid glucuronidation - Gene Ontology Molecular Function:
- glucuronosyltransferase activity
UDP-glycosyltransferase activity - Gene Ontology Cellular Component:
- integral component of membrane
UDP-N-acetylglucosamine transferase complex - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Glycosyltransferase
Membrane
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix