Names & Taxonomy

Uniprot ID:
Q6NUS8
Entry Name:
UD3A1_HUMAN
Status:
reviewed
Protein Names:
UDP-glucuronosyltransferase 3A1 (UDPGT 3A1) (EC 2.4.1.17)
Gene Names:
UGT3A1
Gene Names Primary:
UGT3A1
Organism:
Homo sapiens (Human)

Structure

Length:
523
Sequence:
MVGQRVLLLVAFLLSGVLLSEAAKILTISTLGGSHYLLLDRVSQILQEHGHNVTMLHQSGKFLIPDIKEEEKSYQVIRWFSPEDHQKRIKKHFDSYIETALDGRKESEALVKLMEIFGTQCSYLLSRKDIMDSLKNENYDLVFVEAFDFCSFLIAEKLVKPFVAILPTTFGSLDFGLPSPLSYVPVFPSLLTDHMDFWGRVKNFLMFFSFSRSQWDMQSTFDNTIKEHFPEGSRPVLSHLLLKAELWFVNSDFAFDFARPLLPNTVYIGGLMEKPIKPVPQDLDNFIANFGDAGFVLVAFGSMLNTHQSQEVLKKMHNAFAHLPQGVIWTCQSSHWPRDVHLATNVKIVDWLPQSDLLAHPSIRLFVTHGGQNSVMEAIRHGVPMVGLPVNGDQHGNMVRVVAKNYGVSIRLNQVTADTLTLTMKQVIEDKRYKSAVVAASVILHSQPLSPAQRLVGWIDHILQTGGATHLKPYAFQQPWHEQYLIDVFVFLLGLTLGTMWLCGKLLGVVARWLRGARKVKKT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
Catalytic Activity:
UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Gene Ontology Go:
integral component of membrane
UDP-N-acetylglucosamine transferase complex
glucuronosyltransferase activity
UDP-glycosyltransferase activity
flavonoid biosynthetic process
flavonoid glucuronidation
Gene Ontology Biological Process:
flavonoid biosynthetic process
flavonoid glucuronidation
Gene Ontology Molecular Function:
glucuronosyltransferase activity
UDP-glycosyltransferase activity
Gene Ontology Cellular Component:
integral component of membrane
UDP-N-acetylglucosamine transferase complex
Keywords:
Alternative splicing
Complete proteome
Glycoprotein
Glycosyltransferase
Membrane
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix

Publication

PubMed ID:
14702039 15372022 15489334