Names & Taxonomy
- Uniprot ID:
- Q6NUK1
- Entry Name:
- SCMC1_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium-binding mitochondrial carrier protein SCaMC-1 (Mitochondrial ATP-Mg/Pi carrier protein 1) (Mitochondrial Ca(2+)-dependent solute carrier protein 1) (Small calcium-binding mitochondrial carrier protein 1) (Solute carrier family 25 member 24)
- Gene Names:
- SLC25A24 APC1 MCSC1 SCAMC1
- Gene Names Primary:
- SLC25A24
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 477
- Sequence:
- MLRWLRDFVLPTAACQDAEQPTRYETLFQALDRNGDGVVDIGELQEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.97 mM for AMP
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
mitochondrion
ATP transmembrane transporter activity
calcium ion binding
structural constituent of ribosome
ATP transport
cellular response to calcium ion
cellular response to oxidative stress
mitochondrial transport
regulation of cell death
translation - Gene Ontology Biological Process:
- ATP transport
cellular response to calcium ion
cellular response to oxidative stress
mitochondrial transport
regulation of cell death
translation - Gene Ontology Molecular Function:
- ATP transmembrane transporter activity
calcium ion binding
structural constituent of ribosome - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Calcium
Complete proteome
Membrane
Metal-binding
Mitochondrion
Mitochondrion inner membrane
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport