Names & Taxonomy
- Uniprot ID:
- Q6JEL2
- Entry Name:
- KLH10_HUMAN
- Status:
- reviewed
- Protein Names:
- Kelch-like protein 10
- Gene Names:
- KLHL10
- Gene Names Primary:
- KLHL10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 608
- Sequence:
- MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYSASTSTLPV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.
- Pathway:
- Protein modification; protein ubiquitination.
- Gene Ontology Go:
- Cul3-RING ubiquitin ligase complex
cytoplasm
cell morphogenesis
fertilization
homeostasis of number of cells within a tissue
male genitalia morphogenesis
male gonad development
protein ubiquitination
spermatid development - Gene Ontology Biological Process:
- cell morphogenesis
fertilization
homeostasis of number of cells within a tissue
male genitalia morphogenesis
male gonad development
protein ubiquitination
spermatid development - Gene Ontology Cellular Component:
- Cul3-RING ubiquitin ligase complex
cytoplasm - Keywords:
- Complete proteome
Cytoplasm
Differentiation
Disease mutation
Kelch repeat
Phosphoprotein
Reference proteome
Repeat
Spermatogenesis
Ubl conjugation pathway