Names & Taxonomy
- Uniprot ID:
- Q6J4K2
- Entry Name:
- NCKX6_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/potassium/calcium exchanger 6, mitochondrial (Na(+)/K(+)/Ca(2+)-exchange protein 6) (Sodium/calcium exchanger protein, mitochondrial) (Solute carrier family 24 member 6) (Solute carrier family 8 member B1)
- Gene Names:
- SLC8B1 NCKX6 NCLX SLC24A6
- Gene Names Primary:
- SLC8B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 584
- Sequence:
- MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).
- Enzyme Regulation:
- ENZYME REGULATION: Strongly inhibited by zinc.
- Gene Ontology Go:
- integral component of mitochondrial membrane
mitochondrial crista
plasma membrane
sarcolemma
calcium:sodium antiporter activity
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
protein homodimerization activity
glucose homeostasis
ion transport
mitochondrial calcium ion homeostasis
mitochondrial calcium ion transport
regulation of cardiac muscle cell membrane potential
regulation of cytosolic calcium ion concentration
regulation of insulin secretion
response to stimulus
transmembrane transport - Gene Ontology Biological Process:
- glucose homeostasis
ion transport
mitochondrial calcium ion homeostasis
mitochondrial calcium ion transport
regulation of cardiac muscle cell membrane potential
regulation of cytosolic calcium ion concentration
regulation of insulin secretion
response to stimulus
transmembrane transport - Gene Ontology Molecular Function:
- calcium:sodium antiporter activity
calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
protein homodimerization activity - Gene Ontology Cellular Component:
- integral component of mitochondrial membrane
mitochondrial crista
plasma membrane
sarcolemma - Keywords:
- Alternative splicing
Antiport
Calcium
Calcium transport
Complete proteome
Glycoprotein
Ion transport
Lithium
Membrane
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Sensory transduction
Sodium
Sodium transport
Transit peptide
Transmembrane
Transmembrane helix
Transport