Names & Taxonomy
- Uniprot ID:
- Q6IWH7
- Entry Name:
- ANO7_HUMAN
- Status:
- reviewed
- Protein Names:
- Anoctamin-7 (Dresden transmembrane protein of the prostate) (D-TMPP) (IPCA-5) (New gene expressed in prostate) (Prostate cancer-associated protein 5) (Transmembrane protein 16G)
- Gene Names:
- ANO7 NGEP PCANAP5 TMEM16G
- Gene Names Primary:
- ANO7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 933
- Sequence:
- MRMAATAWAGLQGPPLPTLCPAVRTGLYCRDQAHAERWAMTSETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRAGSPAKPRIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVDQQDVQDGNTTVHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPPEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAASAPMTAPNPITGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVSRSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVLFGTNGTKDEQPEGSELSSHWTPFTVPKASQLQQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane
Function
- Function:
- Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.
- Gene Ontology Go:
- cell junction
cytosol
endoplasmic reticulum
integral component of membrane
intracellular
nucleus
plasma membrane
intracellular calcium activated chloride channel activity
phospholipid scramblase activity
calcium activated galactosylceramide scrambling
calcium activated phosphatidylcholine scrambling
calcium activated phosphatidylserine scrambling
chloride transport
ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- calcium activated galactosylceramide scrambling
calcium activated phosphatidylcholine scrambling
calcium activated phosphatidylserine scrambling
chloride transport
ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- intracellular calcium activated chloride channel activity
phospholipid scramblase activity - Gene Ontology Cellular Component:
- cell junction
cytosol
endoplasmic reticulum
integral component of membrane
intracellular
nucleus
plasma membrane - Keywords:
- Alternative splicing
Cell junction
Cell membrane
Complete proteome
Cytoplasm
Endoplasmic reticulum
Glycoprotein
Lipid transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport