Names & Taxonomy
- Uniprot ID:
- Q6IB77
- Entry Name:
- GLYAT_HUMAN
- Status:
- reviewed
- Protein Names:
- Glycine N-acyltransferase (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) (EC 2.3.1.71) (HRP-1(CLP))
- Gene Names:
- GLYAT ACGNAT CAT GAT
- Gene Names Primary:
- GLYAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 296
- Sequence:
- MMLPLQGAQMLQMLEKSLRKSLPASLKVYGTVFHINHGNPFNLKAVVDKWPDFNTVVVCPQEQDMTDDLDHYTNTYQIYSKDPQNCQEFLGSPELINWKQHLQIQSSQPSLNEAIQNLAAIKSFKVKQTQRILYMAAETAKELTPFLLKSKILSPNGGKPKAINQEMFKLSSMDVTHAHLVNKFWHFGGNERSQRFIERCIQTFPTCCLLGPEGTPVCWDLMDQTGEMRMAGTLPEYRLHGLVTYVIYSHAQKLGKLGFPVYSHVDYSNEAMQKMSYTLQHVPIPRSWNQWNCVPL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
- Catalytic Activity:
- Acyl-CoA + glycine = CoA + N-acylglycine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=57.9 mM for benzoyl-CoA
- Cross Reference Drug Bank:
- DB00145
- Gene Ontology Go:
- extracellular exosome
mitochondrial matrix
mitochondrion
glycine N-acyltransferase activity
glycine N-benzoyltransferase activity
transferase activity, transferring acyl groups
acyl-CoA metabolic process
glycine metabolic process
monocarboxylic acid metabolic process
response to toxic substance
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- acyl-CoA metabolic process
glycine metabolic process
monocarboxylic acid metabolic process
response to toxic substance
small molecule metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glycine N-acyltransferase activity
glycine N-benzoyltransferase activity
transferase activity, transferring acyl groups - Gene Ontology Cellular Component:
- extracellular exosome
mitochondrial matrix
mitochondrion - Keywords:
- Acetylation
Acyltransferase
Alternative splicing
Complete proteome
Detoxification
Mitochondrion
Polymorphism
Reference proteome
Transferase - Interacts With:
- P60410; Q7Z3S9