Names & Taxonomy
- Uniprot ID:
- Q6IA69
- Entry Name:
- NADE_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) (NAD(+) synthetase)
- Gene Names:
- NADSYN1
- Gene Names Primary:
- NADSYN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 706
- Sequence:
- MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWTPHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMASKNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLALQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIGGISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSVYGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAENYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD
- Proteomes:
- UP000005640
Function
- Pathway:
- Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.
- Catalytic Activity:
- ATP + deamido-NAD(+) + L-glutamine + H(2)O = AMP + diphosphate + NAD(+) + L-glutamate.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.49 mM for deamido-NAD(+)
- Active Site:
- ACT_SITE 357 357
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytoplasm
cytosol
ATP binding
glutaminase activity
NAD+ synthase (glutamine-hydrolyzing) activity
NAD biosynthetic process
NAD metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- NAD biosynthetic process
NAD metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- ATP binding
glutaminase activity
NAD+ synthase (glutamine-hydrolyzing) activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Ligase
NAD
Nucleotide-binding
Polymorphism
Reference proteome - Interacts With:
- Q9H614