Names & Taxonomy
- Uniprot ID:
- A0A024R1Y2
- Entry Name:
- A0A024R1Y2_HUMAN
- Status:
- unreviewed
- Protein Names:
- ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)
- Gene Names:
- ACLY hCG_19718
- Gene Names Orf:
- hCG_19718
- Gene Names Primary:
- ACLY
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1091
- Sequence:
- MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.
- Catalytic Activity:
- ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.
- Active Site:
- ACT_SITE 750 750 Tele-phosphohistidine intermediate.
- Gene Ontology Go:
- cytoplasm
nucleoplasm
plasma membrane
ATP binding
ATP citrate synthase activity
cofactor binding
lyase activity
metal ion binding
acetyl-CoA biosynthetic process
citrate metabolic process
lipid metabolic process - Gene Ontology Biological Process:
- acetyl-CoA biosynthetic process
citrate metabolic process
lipid metabolic process - Gene Ontology Molecular Function:
- ATP binding
ATP citrate synthase activity
cofactor binding
lyase activity
metal ion binding - Gene Ontology Cellular Component:
- cytoplasm
nucleoplasm
plasma membrane - Keywords:
- ATP-binding
Cytoplasm
Lipid biosynthesis
Lipid metabolism
Lyase
Magnesium
Metal-binding
Nucleotide-binding
Transferase
Publication
- PubMed ID:
- 11181995